25606-96-6Relevant academic research and scientific papers
A Sequential Acyl Thiol-Ene and Thiolactonization Approach for the Synthesis of δ-Thiolactones
McCourt, Ruairí O.,Scanlan, Eoin M.
, p. 3460 - 3464 (2019/05/10)
A novel strategy for the synthesis of δ-thiolactones from inexpensive and readily available ?-unsaturated esters has been developed. This strategy incorporates a radical acyl thiol-ene reaction as the key C-S bond forming step. Cyclization is achieved via a Steglich-type thiolactonization of 5-mercaptopentanoic acids. We report the facile and scalable synthesis of δ-thiolactones in moderate to good yield under mild reaction conditions with tolerance for a range of functional groups.
CLEAVAGE OF THE PHENACYL ESTERS OF CARBOXYLIC AND THIOCARBOXYLIC ACIDS BY METAL ALKOXIDES
Morozov, A. A.
, p. 1138 - 1143 (2007/10/02)
During the cleavage of phenacyl esters with general formula XC6H4COCH2OCOR by metal alkoxides in alcohols and in ether-alcohol solutions the acids, esters, and ethers are formed as a result of cleavage of the C-C bond.The solvent participates in the formation of the ether and gives rise to transesterification of RCOOCH3 with catalytic participation of the metal alkoxide.The reactivity of the phenacyl esters of the thio acids is much higher.Before dissociation the esters of substituted benzoins C6H5COCH(OCOCH3).C6H4X-4 undergo irreversible rearrangement with the formation of isomeric products.
