2561-28-6

Basic information

• Product Name: 2-((perfluorophenyl)methyl)isoindoline-1,3-dione
• Synonyms: 2-((perfluorophenyl)methyl)isoindoline-1,3-dione
• CAS NO: 2561-28-6
• Molecular Weight: 327.21
• Mol File: 2561-28-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-((perfluorophenyl)methyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((perfluorophenyl)methyl)isoindoline-1,3-dione(2561-28-6)
• EPA Substance Registry System: 2-((perfluorophenyl)methyl)isoindoline-1,3-dione(2561-28-6)

Safety Data

• Hazardous Substances Data: 2561-28-6(Hazardous Substances Data)

Upstream product

• 118-29-6 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione 
• 363-72-4 Pentafluorobenzene 
• 1074-82-4 potassium phtalimide 
• 1765-40-8 (bromomethyl)pentafluorobenzene 

Downstream Products

• 440-60-8 (2,3,4,5,6-pentafluorophenyl)methanol 
• 1548-77-2 2,3,4,5,6-pentafluorobenzylamine 

Relevant articles and documents

COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME

Disclosed are compounds of general formula (I) that promote readthrough of a premature termination codon (PTC) of an RNA molecule in a translation system, and their use, alone or in combination with other compounds, such as aminoglycoside, to treat diseases or disorders ameliorated by modulation of a premature termination codon (PTC) of an RNA molecule in a translation system. The disorder or disease may be Dystrophic epidermolysis bullosa, Batten disease, Duchenne muscular dystrophy, cancer, and spinal muscular atrophy. Ar-L-B (I)

Superelectrophilic Tscherniac amidomethylation of aromatics with N-hydroxymethylphthalimide in trifluoromethanesulfonic acid

N-Hydroxymethylphthalimide in trifluoromethanesulfonic acid (triflic acid) reacts readily at room temperature with benzene, halo-, polyhalo- and halonitrobenzenes to give high yields of the corresponding α-amidomethylated products. The scope of the α-amidomethylation reaction is substantially extended by the studied system, which is considered to involve diprotonated N-hydroxymethylphthalimide as the de facto superelectrophilic reagent.