2562-79-0Relevant academic research and scientific papers
Phosphotungstic acid mediated, microwave assisted solvent-free green synthesis of highly functionalized 2?-spiro and 2, 3-dihydro quinazolinone and 2-methylamino benzamide derivatives from aryl and heteroaryl 2-amino amides
Novanna, Motakatla,Kannadasan, Sathananthan,Shanmugam, Ponnusamy
, p. 201 - 206 (2019)
Phosphotungstic acid has been found as green catalyst for the synthesis of spiro and cyclized quinazolinones and 2-amino substituted carboxamide under microwave irradiation and solvent-free condition has been developed. The scope of the reaction has been demonstrated for a variety of aldehydes and ketones with O-amino amides such as 2-amino-benzamide, 2-amino-5-iodo benzamide, 3-aminothiophene-2-carboxamide, 3-aminobenzofuran-2-carboxamide and 2-aminopyridine-3-carboxamides. The reaction afforded spiro-, cyclized quinazolinones and 2-amino substituted carboxamide derivatives within few minutes of irradiation in excellent yield. Plausible mechanism for the formation of products is provided. Synthetic utility of 1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 3a has been demonstrated by synthesis of 1,4-di(1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one) buta-1,3-diyne 12, 1′-((1-benzyl-1H-1,2,3-triazol-4-yl) methyl)-1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 13 and 1′-phenyl-1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 14 under standard protocols.
Chemoselective synthesis of 2-Aryl-1-arylmethyl-1H-benzo[d]imidazoles using indion 190 resin as a heterogeneous recyclable catalyst
Reddy, Srinivasula,Reddy, N.C. Gangi,Reddy, T. Ram,Lingappa,Reddy, Bodireddy Mohan
experimental part, p. 304 - 307 (2011/06/26)
The synthesis of 1,2-disubstituted benzimidazoles by the reaction of an o-phenylenediamine and various aromatic aldehydes in the presence of Indion 190 resin was reported. In a 50 mL, round-bottom flask, o-phenylenediamine and an aromatic aldehyde were st
