Tetrahedron Letters p. 201 - 206 (2019)
Update date:2022-08-02
Topics:
Novanna, Motakatla
Kannadasan, Sathananthan
Shanmugam, Ponnusamy
Phosphotungstic acid has been found as green catalyst for the synthesis of spiro and cyclized quinazolinones and 2-amino substituted carboxamide under microwave irradiation and solvent-free condition has been developed. The scope of the reaction has been demonstrated for a variety of aldehydes and ketones with O-amino amides such as 2-amino-benzamide, 2-amino-5-iodo benzamide, 3-aminothiophene-2-carboxamide, 3-aminobenzofuran-2-carboxamide and 2-aminopyridine-3-carboxamides. The reaction afforded spiro-, cyclized quinazolinones and 2-amino substituted carboxamide derivatives within few minutes of irradiation in excellent yield. Plausible mechanism for the formation of products is provided. Synthetic utility of 1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 3a has been demonstrated by synthesis of 1,4-di(1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one) buta-1,3-diyne 12, 1′-((1-benzyl-1H-1,2,3-triazol-4-yl) methyl)-1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 13 and 1′-phenyl-1′H-spiro[fluorene-9,2′-quinazolin]-4′(3′H)-one 14 under standard protocols.
View MoreContact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Wuhan Jadechem International Trade Co.,Ltd.
website:http://www.jadechem-intl.com
Contact:+86-27-83527060
Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
Shanghai Mintchem Development ., Ltd
Contact:0086 21 5190 8570
Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Shandong Yaroma Perfumery Co., Ltd.
Contact:+86- 531- 88024598
Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
Changde Yungang Biotechnology Co., Ltd
website:http://www.cdyg.com
Contact:+86-736-7391178
Address:Qiaonan Industrial Park, Changde City, Hunan Province
Doi:10.1007/s10562-017-2275-2
(2018)Doi:10.1016/S0022-328X(99)00501-X
(1999)Doi:10.3987/COM-05-10335
(2005)Doi:10.1002/cjoc.201400300
(2014)Doi:10.1248/cpb.47.1679
(1999)Doi:10.1016/S0277-5387(99)00285-5
(1999)