25622-74-6

Usage

Uses

Used in Pharmaceutical Industry:
1-(2 3 4 5 6-PENTAFLUOROPHENYL)-1-PROPA& is used as an intermediate in the synthesis of various pharmaceutical compounds. Its high reactivity and ability to undergo chemical transformations make it a crucial component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2 3 4 5 6-PENTAFLUOROPHENYL)-1-PROPA& is utilized as a key intermediate for the production of various agrochemicals. Its versatility in chemical reactions allows for the creation of effective compounds used in agriculture to protect crops and enhance their growth.
Used in Organic Synthesis:
1-(2 3 4 5 6-PENTAFLUOROPHENYL)-1-PROPA& is also employed in organic synthesis for the creation of complex molecules. Its reactivity and capacity for chemical transformations make it an essential building block in the development of novel compounds with potential applications in various industries.

InChI:InChI=1/C9H7F5O/c1-2-3(15)4-5(10)7(12)9(14)8(13)6(4)11/h3,15H,2H2,1H3

Upstream product

• 15948-70-6 1,2,3,4,5-pentafluoro-6-propenyl-benzene 
• 1076-44-4 pentafluorophenyl lithium 
• 123-38-6 propionaldehyde 

Relevant academic research and scientific papers

METHOD FOR THE ORGANOMETALLIC PRODUCTION OF ORGANIC INTERMEDIATE PRODUCTS BY HALOGEN-METAL EXCHANGE REACTIONS

The invention relates to a method for producing aryllithium compounds and to their reaction with suitable electrophiles to obtain compounds of formula (V), by reacting halogen aromatics (I) with lithium metal to obtain an aromatic lithium compound (II), which, as a lithiation agent, reacts with aromatic halogen compounds (III) in a halogen-metal exchange reaction to form the corresponding lithium aromatics (IV). Said aromatics can be reacted in an additional step with a corresponding electrophile to form the desired product (V). Said method is illustrated by equation (I), in which Ar represents phenyl, pyridyl or naphthyl, which are optionally substituted with a radical from the group consisting of methyl, primary, secondary or tertiary alkyl, cycloalkyl, phenyl, substituted phenyl, aryl, heteroaryl, alkoxy, dialkylamino, alkylthio, fluoro, bromo; Hal1 = fluorine, chlorine, bromine or iodine, Hal2 = chlorine, bromine or iodine; the groups X1-5 independently of one another represent either carbon, or the group XiRi (i = 1-5) represents nitrogen, or two respective adjacent groups XiRi, linked by a formal double bond, together represent O (furane), S (thiophene), NRH or NRi (pyrroles). The groups R1-5 represent substituents from the group containing hydrogen, methyl, primary, secondary or tertiary, cyclic or acyclic alkyl groups with 2 to 12 C atoms, in which optionally one or more hydrogen atoms are replaced by fluorine or chlorine, e.g. CF3, substituted cyclic or acyclic alkyl groups, alkoxy, dialkylamino, alkylamino, arylamino, diarylamino, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, dialkyl-, arylalkyl- or diarylaminocarbonyl, monoalkyl- or monoarylaminocarbonyl, CO2-, alkyl- or aryloxycarbonyl, hydroxyalkyl, alkoxyalkyl, fluorine or chlorine, nitro, cyano, aryl- or alkylsulphone, aryl- or alkylsulphonyl, or two respective groups R1-5 together can represent an aromatic, heteroaromatic or aliphatic fused ring.

An exceptional hydroboration of substituted fluoroolefins providing tertiary alcohols

Figure presented A rare hydroboration-oxidation providing 3°-alcohols has been achieved in the case of 1,1,2-perfluoroalkyl(aryl)ethylenes. The hydroboration of substituted perfluoroalkyl(aryl)ethylenes with dichloroborane reveals that the regioselectivit