256229-10-4

Upstream product

• 1450842-95-1 C₁₉H₂₂OS₂ 
• 122-78-1 phenylacetaldehyde 
• 13674-16-3 methyl 2-hydroxy-3-phenylpropanoate 
• 828-01-3 phenyllactic acid 
• 6052-66-0 1-phenyl-3-buten-2-ol 
• 380892-92-2 (2RS)-2-O-benzyl-1-phenyl-3-buten-2-ol 
• 110298-77-6 α-Benzyloxyhydrozimtsaeuremethylester 

Downstream Products

• 98944-52-6 (2R,3S)-3-Benzyloxy-2-hydroxy-butyronitrile 
• 851981-40-3 2-O-benzyl-1-phenyl-7-octen-2,3-diol 
• 102-16-9 benzyl 2-phenylacetate 
• 3085-54-9 N-(4-methylphenyl)formamide 
• 18531-94-7 (R)-1,1'-Bi-2-naphthol 
• 13959-92-7 benzyl triethylsilyl ether 
• 17942-89-1 triethyl-(3-phenyl-propenyloxy)-silane 

Relevant academic research and scientific papers

Novel antimycin derivative containing 3-hydroxybenzoic acid group and preparation method and application thereof

The invention relates to the technical field of medicinal chemistry, in particular to a novel-structure novel antimycin derivative containing 3-hydroxybenzoic acid group, produced by fermentation of streptomyces S.conglobates ATCC 31005, and a preparation method and application thereof in preparation of antitumor drugs. The molecular structure of the novel antimycin generally contains a 3-N-formylaminosalicylic acid group, while the molecular structure of the UAT-B-E provided by the invention is correspondingly provided with a 3-hydroxybenzoic acid group. An anti-tumor cell test finds that theinhibitory activity of UAT-B-E on human lung cancer cells, colorectal cancer cells and melanoma cells is equivalent to that of a control drug Cisplatin, and the toxicity to non-cancer cell lines is weak, so that UAT-B-E is expected to be developed into a tumor inhibitor.

Aniline mediated oxidative C-C bond cleavage of α-alkoxy aldehydes in air and a model reaction for the synthesis of α-(d)-amino acid derivatives

A metal-free and 4-methyl aniline mediated method for the oxidative C-C bond cleavage has been developed. The reaction proceeds in air using molecular oxygen as the oxidant, affording one-carbon shortened esters in moderate to good yields within a short time. Moreover, it provides a model reaction for the highly enantioselective synthesis of (d)-serine esters by combining with a l-proline catalyzed Mannich reaction.

Facially controlled C-methylation of oxolanyl and cyclopentyl acetate enolates: Application to the total synthesis of (+)-nephromopsinic acid

The stereoselectivity of the C-methylation of oxolanyl and cyclopentyl acetate enolates 5a-22a was investigated. The configuration of the C-methyl diastereomers was elucidated by a combination of crystal structure analysis, NMR spectroscopy and chemical correlations. Generally, the methylation proceeded re*-selectively, although with very different degrees of selectivity. The most important stereodirecting effect was a steric one exerted by the 5-phenethyl substituent, and this steric effect was strongly increased by the stereodirecting effect of a 3-OR group. Contrary to previous literature evidence, the endocyclic oxolanyl oxygen does not exert an effect. These findings were applied in a highly stereoselective synthesis of (+)-nephromopsinic acid (94). Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Almond oxynitrilase-catalyzed transformation of aldehydes is strongly influenced by naphthyl and alkoxy substituents

Different α- and β-substituted aldehydes have been submitted to the catalytic action of almond oxynitrilase (PaHNL), in order to explore the influence of a stereocenter already present in the substrate on the selectivity of this enzyme. The results indicate that naphthyl and alkoxy substituents in the α- and also in the β-position to the aldehyde group significantly influence the stereochemical outcome of the PaHNL-catalyzed transformation.