256240-42-3Relevant academic research and scientific papers
Retention of the cis proline conformation in tripeptide fragments of bovine pancreatic ribonuclease A containing a non-natural proline analogue, 5,5-dimethylproline
An, Seong Soo A.,Lester, Cathy C.,Peng, Jin-Lin,Li, Yue-Jin,Rothwarf, David M.,Welker, Ervin,Thannhauser, Theodore W.,Zhang,Tam, James P.,Scheraga, Harold A.
, p. 11558 - 11566 (2007/10/03)
Attention is focused on L-5,5-dimethylproline (dmP) as a substitute to lock L-proline (Pro) in a cis conformation in peptides and proteins, to prevent cis/trans isomerization when a protein with cis X-Pro peptide groups unfolds. Procedures have been devel
