146954-59-8

Basic information

• Product Name: 5,5-diMethyl-Proline
• Synonyms: 5,5-diMethyl-Proline;5,5-DiMethylpyrrolidine-2-carboxylic acid
• CAS NO: 146954-59-8
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Mol File: 146954-59-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 194-196 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 246.2±33.0 °C(Predicted)
• Appearance: /
• Density: 1.057±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.37±0.40(Predicted)
• CAS DataBase Reference: 5,5-diMethyl-Proline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-diMethyl-Proline(146954-59-8)
• EPA Substance Registry System: 5,5-diMethyl-Proline(146954-59-8)

Safety Data

• Hazardous Substances Data: 146954-59-8(Hazardous Substances Data)

Usage

General Description

5,5-diMethyl-Proline, also known as DMP, is a chemical compound that belongs to the proline family of amino acids. It is a cyclic amino acid with a molecular formula of C7H13NO2 and a molecular weight of 143.18 g/mol. DMP is a chiral compound with two enantiomeric forms, and it is commonly used as a chiral auxiliary in organic synthesis reactions to induce stereochemical control. It is also used in the production of pharmaceuticals and agrochemicals due to its unique stereochemical properties. Additionally, DMP has potential applications in the development of novel materials and bioactive compounds. Overall, 5,5-diMethyl-Proline is a versatile compound with various potential uses in the fields of chemistry, pharmaceuticals, and materials science.

Upstream product

• 61856-86-8 1-hydroxy-2(RS)-cyano-5,5-dimethylpyrrolidine 
• 609354-96-3 3-[1,3]Dioxolan-2-yl-1,1-dimethyl-propylamine 
• 905706-74-3 ethyl 5,5-dimethyl-1-tosylpyrrolidine-2-carboxylate 
• 3317-61-1 5,5-Dimethyl-1-pyrroline N-oxide 
• 5165-28-6 5,5-dimethyl-2-pyrrolidone 
• 2045-76-3 2,2-dimethyl-3,4-dihydro-2H-pyrrole 
• 65320-65-2 5,5-dimethylpyrrolidine-2-carbonitrile 
• 61856-88-0 1-hydroxy-5,5-dimethyl-pyrrolidine-2-carboxylic acid 

Downstream Products

• 900158-99-8 1-(tert-Butoxycarbonyl)-5,5-dimethylpyrrolidine-2-carboxylic acid 
• 146954-62-3 Boc-L-Phe-DL-5,5-Me₂Pro-OMe 
• 256240-42-3 Ac-Asn-dmP-Tyr 
• 565232-64-6 (S)-1-[(S)-2-Amino-3-(4-tert-butoxy-phenyl)-propionyl]-5,5-dimethyl-pyrrolidine-2-carboxylic acid 
• 900159-00-4 2-[(1-tert-butoxycarbonyl-5,5-dimethyl-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid dibenzyl ester 
• 900159-01-5 (S)-2-{[(S)-1-(2-Benzyloxycarbonylamino-acetyl)-5,5-dimethyl-pyrrolidine-2-carbonyl]-amino}-pentanedioic acid dibenzyl ester 

Relevant articles and documents

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

ANALOGS OF GLYCYL-PROLYL-GLUTAMATE

Embodiments of this invention include novel analogs of Glycyl-Prolyl-Glutamate (GPE) and compositions containing such analogs of GPE. Of these, certain analogs have modified proline residues. Other embodiments of this invention include uses of analogs of GPE to protect neural cells from degeneration and/or death in response to injury or disease. Disorders treatable with compounds and compositions of this invention include hypoxia/ischemia, toxic injury, and chronic neurodegenerative disorders including Parkinson''s disease.

Synthesis of proline-modified analogues of the neuroprotective agent glycyl-L-prolyl-glutamic acid (GPE)

The synthesis of ten proline-modified analogues of the neuroprotective tripeptide GPE is described. Five of the analogues incorporate a proline residue with a hydrophobic group at C-2 and two further analogues have this side chain locked into a spirolactam ring system. The pyrrolidine ring was also modified by replacing the γ-CH2 group with sulfur and/or incorporation of two methyl groups at C-5.