25627-39-8Relevant articles and documents
SYNTHESIS OF DOTHIEPIN AND DOXEPIN BY GRIGNARD REACTIONS IN TOLUENE
Jalander, Lars,Oksanen, Lasse,Taehtinen, Johanna
, p. 3349 - 3352 (2007/10/02)
The tricyclic antidepressant agents 11-(3-N,N-dimethylaminopropylidene)-6H,11H-dibenzo--thiepin hydrochloride (Dothiepin) and 11-(3-N,N-dimethylaminopropylidene)-6H,11H-dibenzo-oxepin hydrochloride (Doxepin) have been prepared in good yield by Grignard reactions in toluene.