256331-30-3

Upstream product

• 256331-29-0 Carbonic acid (3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-oxo-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-28-9 Carbonic acid (5R,6R,7R,8R)-6,7-bis-ethoxycarbonyloxymethyl-8-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yl ester ethyl ester 
• 518-28-5 podofilox 
• 78339-51-2 podophyllol 

Downstream Products

• 256331-32-5 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-42-7 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-methyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-37-0 Carbonic acid (6R,7R,8R)-6-ethoxycarbonyloxymethyl-8-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl ester ethyl ester 
• 256331-36-9 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-iodo-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-33-6 Methanesulfonic acid (1S,2S,3R)-1,2-bis-ethoxycarbonyloxymethyl-3-(6-formyl-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-propyl ester 
• 256331-34-7 6-[(1R,2S,3S)-4-Ethoxycarbonyloxy-2-ethoxycarbonyloxymethyl-3-methanesulfonyloxy-1-(3,4,5-trimethoxy-phenyl)-butyl]-benzo[1,3]dioxole-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of (-)-4-aza-4-deoxypodophyllotoxin from (-)-podophyllotoxin

(-)-4-Aza-4-deoxypodophyllotoxin (4) was synthesized from (-)-podophyllotoxin (1) through C-ring cleavage, Curtius rearrangement and intramolecular N-alkylation. Analogue 4 showed potent cytotoxicity against P388 leukemia cells.