78339-51-2

Usage

Uses

Used in Pharmaceutical Industry:
Podophyllol is used as a topical treatment for genital warts, as it effectively inhibits cell division and viral replication in the affected area. It is applied in the form of a cream or solution, and it is crucial to follow the precise instructions for application to avoid contact with healthy skin.
Used in Antiviral Applications:
Due to its antiviral properties, podophyllol is utilized in the development of antiviral medications, targeting the inhibition of viral replication and providing relief to patients suffering from viral infections.

Upstream product

• 518-28-5 podofilox 
• 139955-57-0 methyl podophyllotoxinate diacetate 

Downstream Products

• 62287-47-2 Anhydropodophyllol 
• 62287-47-2 neoanhydropodophyllol 
• 256331-34-7 6-[(1R,2S,3S)-4-Ethoxycarbonyloxy-2-ethoxycarbonyloxymethyl-3-methanesulfonyloxy-1-(3,4,5-trimethoxy-phenyl)-butyl]-benzo[1,3]dioxole-5-carboxylic acid 
• 256331-33-6 Methanesulfonic acid (1S,2S,3R)-1,2-bis-ethoxycarbonyloxymethyl-3-(6-formyl-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-propyl ester 
• 256331-31-4 Carbonic acid (2R,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-hydroxymethyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-30-3 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-hydroxymethyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-36-9 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-iodo-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-42-7 Carbonic acid (2S,3S,4R)-3-ethoxycarbonyloxymethyl-2-hydroxy-4-(6-methyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-35-8 Carbonic acid (2R,3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 256331-37-0 Carbonic acid (6R,7R,8R)-6-ethoxycarbonyloxymethyl-8-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl ester ethyl ester 
• 256331-29-0 Carbonic acid (3S,4R)-3-ethoxycarbonyloxymethyl-4-(6-formyl-benzo[1,3]dioxol-5-yl)-2-oxo-4-(3,4,5-trimethoxy-phenyl)-butyl ester ethyl ester 
• 683805-37-0 [(4aR,5S,6S,11bR)-6-(2-Chloro-3,4,5-trimethoxy-phenyl)-2-phenyl-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-yl]-acetic acid 
• 683805-40-5 2-[(4aR,5R,6R,11bR)-2-Phenyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-yl]-acetamide 
• 683805-38-1 Methanesulfonic acid (4aR,5R,6R,11bR)-2-phenyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthren-5-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis of podophyllotoxin analogues: δ-lactone-containing picropodophyllin, podophyllotoxin and 4′-demethyl-epipodophyllotoxin derivatives

Non-epimerizable cis and trans δ-lactone analogues of podophyllotoxin have been prepared. Thus the synthesis of the cis isomer 4 has been achieved in 8 steps and 4% overall yield from podophyllotoxin 1 via the reduction of the γ lactone ring into the tran

Cytotoxic cyclolignans related to podophyllotoxin

The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of

Synthesis of (-)-4-aza-4-deoxypodophyllotoxin from (-)-podophyllotoxin

(-)-4-Aza-4-deoxypodophyllotoxin (4) was synthesized from (-)-podophyllotoxin (1) through C-ring cleavage, Curtius rearrangement and intramolecular N-alkylation. Analogue 4 showed potent cytotoxicity against P388 leukemia cells.

Carbon-13 NMR Chemical Shifts of some Podophyllum Lignans and Analogues

Carbon-13 nmr chemical shifts of a number of podophyllum lignans, podophyllotoxin, 4′-demethylpodophyllotoxin, podophyllotoxone, desoxypodophyllotoxin and their derivatives have been determined. The derivatives include 1-naphthol, quinone, diol and tetrahydrofuran compounds.

LIGNANS FROM POLAR EXTRACTS OF JUNIPERUS THURIFERA

Three new natural lignans, methyl deoxypodophyllotoxinate, podophyllotoxinic acid and 7β-hydroxydihydrosesamin, 11 known lignans and two cinnamyl alcohols were isolated and identified from a chloroform extract of Juniperus thurifera leaves.Assignment of the (13)C NMR spectrum of β-methyl peltatin B was also performed through direct and long-range heteronuclear 2D NMR analysis, amending previous assignments. Key Word Index - Juniperus thurifera; Cupressaceae; methyl deoxypodophyllotoxinate; podophyllotoxinic acid; 7β-hydroxydihydrosesamin; lignans.