256331-94-9

Upstream product

• 13636-26-5 N'-(4-chloro-phenyl)-N,N-dimethyl-guanidine 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 35755-44-3 1-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]ethan-1-one 

Downstream Products

• 256332-25-9 1,4-bis(4-chlorophenyl)-2-(dimethylamino)-1H-imidazole-5-carbaldehyde 

Relevant academic research and scientific papers

A simple route to new N(3)-substituted 5-aryl-2-(dialkylamino)-1,3- oxazolium salts and N(1)-substituted 4-aryl-2-(dialkylamino)-1H-imidazoles

In the reaction of N,N-dialkyl-dichloromethaniminium chlorides 11 with 2-aminoacetophenones 12, a general and simple route to heretofore unknown 5- aryl-substituted 2-(dialkylamino)-1,3-oxazolium salts 13 and 5-aryl- substituted 2-(dialkylamino)oxazoles 14 was found. From the 2-(dialkylamino)- 1,3-oxazoles 14, the corresponding oxazolium salts 13 were obtained after alkylation with (MeO)2SO2. The new oxazolium salts 13 were converted to 1- substituted 4-aryl-2-(dialkylamino)-1H-imidazoles 9 by treatment with NH4 OAc. The possible use of these 1H-imidazoles as dye educts was explored. Analytical data, as well as AM1 calculations, reveal some remarkable differences between the structures of the neutral imidazoles 9 and their positively charged oxazolium precursors 13.