35755-44-3Relevant academic research and scientific papers
A one-pot and three-component synthetic approach for the preparation of asymmetric and multi-substituted 1,4-dihydropyrazines
Peytam, Fariba,Adib, Mehdi,Shourgeshty, Reihaneh,Rahmanian-Jazi, Mahmoud,Jahani, Mehdi,Larijani, Bagher,Mahdavi, Mohammad
supporting information, (2019/11/11)
An efficient, one-pot and three-component synthesis of a new series of 2-acyl-3,4,6-triaryl-1,4-dihydropyrazines is described. This two-step strategy involves treatment of phenacyl bromides and anilines to give the nucleophilic substitution intermediate f
New efficient synthesis of 1,4-benzodiazepin-5-ones by catalytic aza-Wittig reaction
Wang, Long,Qin, Ru-Qing,Yan, Hong-Ye,Ding, Ming-Wu
, p. 3522 - 3528 (2015/11/17)
1,4-Benzodiazepin-5-ones were synthesized in 71-89% yields from 2-isocyanato-N-(2-oxoalkyl)benzamides via a new catalytic intramolecular aza-Wittig reaction. Starting from easily accessible phthalic anhydride and α-arylamino ketones, the corresponding 2-{[(2-oxoalkyl)amino]carbonyl}benzoic acids underwent sequential formation of the acid azide and Curtis rearrangement to give 2-isocyanato-N-(2-oxoalkyl)benzamides that were reacted directly to give the final 2,4-diaryl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones and 4-aryl-2-tert-butyl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones.
Synthesis, Characterization, and Antibacterial Activity of Some Novel Substituted Imidazole Derivatives via One-pot Three-Component
Ramagiri, Raj Kumar,Thupurani, Murali Krishna,Vedula, Rajeswar Rao
, p. 1713 - 1717 (2015/11/09)
A simple and highly efficient one-pot, three-component synthesis of novel substituted imidazole derivatives has been reported by the reaction of 3-(2-bromoacetyl)-2H-chromen-2-one, ammonium thiocyanate, and phenacyl aniline in the presence of acetic acid
Synthesis, antibacterial activity and binding mode analysis of some novel 1,4-diaryl imidazole thiones
Ganguly, Swastika,Singh, Nalini,Upadhyay, Arpita
, p. 419 - 424 (2019/01/21)
A novel series of fifteen diaryl imidazole thiones 2a-o was synthesized by reacting the corresponding 1-(aryl)-2-(arylamino)-ethanones 1 with ammonium thiocyanate. The compounds have been characterized on the basis of elemental analysis and spectral data.
A rapid and direct access to symmetrical/unsymmetrical 3,4-diarylmaleimides and pyrrolin-2-ones
Pal, Manojit,Swamy, Nalivela Kumara,Hameed, P. Shahul,Padakanti, Srinivas,Yeleswarapu, Koteswar Rao
, p. 3987 - 3997 (2007/10/03)
1,8-Diazabicyclo[5.4.0]undec-7ene (DBU) facilitated the oxidative cyclization of phenacyl amide in the presence of atmospheric oxygen under environmentally friendly conditions. The reaction has been studied under various conditions and a plausible mechani
Hypervalent iodine mediated syntheses of heterocycles: One-pot facile syntheses of 1,4-diaryl-2-mercaptoimidazoles, 2-(α-anilinoacetyl)thiophenes and 1-aryl-2-mercapto-4-(2-thienyl)imidazoles from aryl/2-thienyl methyl ketones
Prakash, Om,Ranjana,Saini, Neena,Goyal, Seema,Tomar, Rajesh K.,Singh, Shiv P.
, p. 116 - 119 (2007/10/02)
Successive treatment of acetophenones (1a-e) or 2-acetylthiophene (4) with benzene, appropriate aniline and KSCN/AcOH leads to the formation of 1,4-diaryl-2-mercaptoimidazoles (3aa-3ea) or 1-aryl-2-mercapto-4-(2-thienyl)imidazoles (6a-f) respectively.This procedure also provides 2(α-anilinoacetyl)thiophenes (5a-f) in one pot from 4.
Research on antibacterial and antifungal agents. VIII. Synthesis and antimicrobial activity of 1,4-diarylpyrroles
Porretta,Biava,Fioravanti,Fischetti,Melino,Venza,Bolle,Tita
, p. 717 - 722 (2007/10/02)
The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against
Nucleophilic Substitution Reactions of Phenacyl Benzenesulphonates with Anilines in Methanol-Acetonitrile Mixtures
Lee, Ikchoon,Shim, Chang Sub,Chung, Soo Young,Lee, Hai Whang
, p. 975 - 982 (2007/10/02)
The nucleophilic substitution reactions of phenacyl benzenesulphonates with anilines in methanol-acetonitrile have been studied.A stronger nucleophile was found to cause less bond cleavage, while a better leaving group led to less bond formation, in compl
