256381-13-2Relevant academic research and scientific papers
NRF2 ACTIVATOR
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Page/Page column 113; 116, (2018/08/20)
Provided are tetrahydroisoquinoline derivatives as Nrf2 activators.
New compounds, pharmaceutical compositions and uses thereof
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Page/Page column 59, (2012/09/05)
The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors
Kendall, Jackie D.,Rewcastle, Gordon W.,Frederick, Raphael,Mawson, Claire,Denny, William A.,Marshall, Elaine S.,Baguley, Bruce C.,Chaussade, Claire,Jackson, Shaun P.,Shepherd, Peter R.
, p. 7677 - 7687 (2008/03/14)
A series of 2-methyl-5-nitrobenzenesulfonohydrazides were prepared and evaluated as inhibitors of PI3K. An isoquinoline derivative shows good selectivity for the p110α isoform over p110β and p110δ, and also demonstrates good in vitro activity in a cell pr
2,5-DIOXOIMIDAZOLIDIN-4-YL ACETAMIDES AND ANALOGUES AS INHIBITORS OF METALLOPROTEINASE MMP12.
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Page 44, (2010/02/06)
The invention provides compounds of formula (I) in which L, X, Y, Z1, Z2, R1, R2, R3 and G2 have the meanings defined in the specification; processes for their preparation; pharmaceutical c
