256394-70-4Relevant academic research and scientific papers
Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway
Peukert, Stefan,Jain, Rishi K.,Geisser, Adrian,Sun, Yingchuan,Zhang, Rui,Bourret, Aaron,Carlson, Adam,DaSilva, Jennifer,Ramamurthy, Arun,Kelleher, Joseph F.
, p. 328 - 331 (2011/03/18)
Ortho-biphenyl carboxamides, originally prepared as inhibitors of microsomal triglyceride transfer protein (MTP) have been identified as novel inhibitors of the Hedgehog signaling pathway. Structure-activity relationship studies for this class of compound
