256399-07-2Relevant academic research and scientific papers
Catalytic enantioselective synthesis of the phosphodiesterase type IV inhibitor (R)-(-)-rolipram via intramolecular C-H insertion process
Anada, Masahiro,Mita, Orie,Watanabe, Hiroko,Kitagaki, Shinji,Hashimoto, Shunichi
, p. 1775 - 1777 (1999)
A new route to the phosphodiesterase type IV inhibitor (R)-(-)-rolipram (1) has been developed, wherein the key step relies on enantioselective intramolecular C-H insertion of N-alkyl-N-4-nitrophenyl-α-methoxycarbonyl- α-diazoacetamide 7 catalyzed by chir
