256409-67-3Relevant academic research and scientific papers
Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors
Aoyama, Yasunori,Uenaka, Masaaki,Kii, Makoto,Tanaka, Mamoru,Konoike, Toshiro,Hayasaki-Kajiwara, Yoko,Naya, Noriyuki,Nakajima, Masatoshi
, p. 3065 - 3075 (2007/10/03)
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h). Copyright
