256424-63-2

Usage

Uses

1. Used in Pharmaceutical Industry:
(-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile is used as a pharmaceutical compound for its potential therapeutic applications. The compound's unique structure may allow it to interact with specific biological targets, making it a candidate for the development of new drugs.
2. Used in Chemical Research:
In the field of chemical research, (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile can be utilized as a starting material or intermediate for the synthesis of other complex organic molecules. Its unique structure may provide new insights into the reactivity and properties of related compounds.
3. Used in Material Science:
The compound may also find applications in material science, where its specific chemical and physical properties could be exploited to develop new materials with unique characteristics. For example, it could be used in the development of advanced coatings, sensors, or other specialized materials.
4. Used in Pesticide Industry:
Given its structural features, (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile may also be evaluated for its potential as a pesticide or insecticide. Its interaction with specific biological targets could make it an effective tool for controlling pests in agriculture.

Upstream product

• 187164-19-8 luliconazole 
• 541-73-1 1,3-Dichlorobenzene 
• 4252-78-2 2,2',4'-trichloroacetophenone 
• 23184-45-4 2-cyanomethyl-imidazole 
• 229334-55-8 (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl methanesulfonate 

Relevant academic research and scientific papers

Imidazole acetonitrile derivative acid salt as well as preparation method and application thereof

The invention relates to an imidazole acetonitrile derivative acid salt as well as a preparation method and an application thereof, belongs to the technical field of drug synthesis, and aims to solve the problem about how to improve stability and increase the yield. The method comprises steps as follows: an imidazole acetonitrile derivative is dissolved in a water-insoluble polar organic solvent, then corresponding acid is added for a salt forming reaction, and the acid salt of the product imidazole acetonitrile derivative is gradually separated out, and applied to preparation of Luliconazole. The acid salt itself has better stability and used as an intermediate for preparing Luliconazole at the same time, the problem of mutual inversion of Z-E configuration in the Luliconazole preparation process can be solved, the Z configuration can be inverted into the E configuration, the configuration inversion stability is guaranteed, and the yield is higher. The effects of simple technology and easiness in operation are also realized.

Method for synthesizing Luliconazole

The invention relates to a method for synthesizing Luliconazole. The method comprises the steps of subjecting m-dichlorobenzene to Friedel-Crafts acylation with chloroacetyl chloride, catalytic chiral reduction with (S)-2-methyl-CBS-oxazaborolidine and esterification with methylsulfonyl chloride so as to obtain (S)-2,2',4'-ethyl trichlorobenzene methanesulfonate, and finally, subjecting (S)-2,2',4'-ethyl trichlorobenzene methanesulfonate to a reaction with carbon disulfide and imidazolyl acetonitrile, thereby obtaining Luliconazole. According to the method, the total yield is about 30%.

EXTERNAL PHARMACEUTICAL COMPOSITION

A pharmaceutical composition for external use, including: i) luliconazole represented by the following structural formula (1) and/or a salt thereof; and ii) one or two or more selected from N-methyl-2-pyrrolidone, propylene carbonate, and crotamiton.