256475-58-8

Basic information

• Product Name: 1-(2-p-tolyl-ethyl)-[1,4]diazepane
• CAS NO: 256475-58-8
• Molecular Weight: 218.342
• Mol File: 256475-58-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-p-tolyl-ethyl)-[1,4]diazepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-p-tolyl-ethyl)-[1,4]diazepane(256475-58-8)
• EPA Substance Registry System: 1-(2-p-tolyl-ethyl)-[1,4]diazepane(256475-58-8)

Safety Data

• Hazardous Substances Data: 256475-58-8(Hazardous Substances Data)

Upstream product

• 505-66-8 1,4-Diazacycloheptane 
• 32327-68-7 p-methyl-2-phenylethyl chloride 
• 699-02-5 4-Methylphenethyl alcohol 

Relevant articles and documents

Non-imidazole histamine H3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H3-antagonists with H1 blocking activities

New 2-(1-Piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazoles were prepared and tested as H1- and H3-receptor antagonists. A number of compounds showed weak H1-antagonistic activity, with pA2 values ranging from 5.5 to 6.1. The simple alkyl substituted, 2-[1-(4-methyl and 4-ethyl)piperazinyl] analogues show increasing, moderate H3-antagonistic activity (pA2=6.0, and pA2=7.0). The compounds with 4-phenylalkyl substitution, for both the piperazinyl and the hexahydro-1H-1,4-diazepin-1-yl homologues series, regardless of the different physicochemical properties of the para substituents at the phenyl ring, showed weak H3-antagonistic activity with pA2 values ranging from 4.4 to 5.6. Copyright (C) 1999 Elsevier Science S.A.