32327-68-7

Basic information

• Product Name: 1-(2-chloroethyl)-4-methylbenzene
• CAS NO: 32327-68-7
• Molecular Formula: C₉H₁₁Cl
• Molecular Weight: 154.6366
• Mol File: 32327-68-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 221°C at 760 mmHg
• Flash Point: 85.2°C
• Density: 1.031g/cm³
• Vapor Pressure: 0.163mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 1-(2-chloroethyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-4-methylbenzene(32327-68-7)
• EPA Substance Registry System: 1-(2-chloroethyl)-4-methylbenzene(32327-68-7)

Safety Data

• Hazardous Substances Data: 32327-68-7(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-4-methylbenzene, also known as 4-(2-Chloroethyl)toluene, is a chemical compound with the molecular formula C9H11Cl. It is a colorless liquid with a chloroethyl group and a methyl group attached to a benzene ring. 1-(2-chloroethyl)-4-methylbenzene is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and perfumes. It is also used as a solvent for resins and as a starting material for the synthesis of other organic compounds. Additionally, it is a common intermediate in the manufacturing of various industrial chemicals. However, it is important to handle this compound with caution as it is toxic, flammable, and can cause skin and eye irritation upon contact.

Upstream product

• 699-02-5 4-Methylphenethyl alcohol 
• 80-41-1 2-chloroethyl tosylate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 13290-16-9 2-(p-tolylthio)-ethanol 
• 593-71-5 Chloroiodomethane 
• 104-87-0 4-methyl-benzaldehyde 
• 6749-78-6 4-methylphenylmagnesium iodide 
• 84648-16-8 C₁₇H₁₅ClO₄ 
• 14503-40-3 2-(4-methylphenyl)ethyl tosylate 

Downstream Products

• 622-97-9 1-ethenyl-4-methylbenzene 
• 79744-75-5 4-methyl-1-methoxyethylbenzene 
• 104-87-0 4-methyl-benzaldehyde 
• 103790-59-6 1-(2-methoxyethyl)-4-methylbenzene 
• 109395-33-7 1-Phenyl-3-<4-tolyl>-propylcyanid 
• 622-96-8 4-methylethylbenzene 
• 59698-41-8 N-[2-(4-methylphenyl)ethyl]piperazine 
• 256475-58-8 1-(2-p-tolyl-ethyl)-[1,4]diazepane 
• 14087-97-9 7-methyl-2-phenyl-3,4-dihydro-2H-naphthalen-1-one 
• 108976-74-5 2-phenyl-4-p-tolyl-butyric acid 
• 1391611-30-5 C₂₃H₂₀N₂O 
• 1391611-27-0 C₂₃H₂₀N₂O 

Relevant articles and documents

Chemoselective Homologation-Deoxygenation Strategy Enabling the Direct Conversion of Carbonyls into (n+1)-Halomethyl-Alkanes

The sequential installation of a carbenoid and a hydride into a carbonyl, furnishing halomethyl alkyl derivatives, is reported. Despite the employment of carbenoids as nucleophiles in reactions with carbon-centered electrophiles, sp3-type alkyl halides remain elusive materials for selective one-carbon homologations. Our tactic levers on using carbonyls as starting materials and enables uniformly high yields and chemocontrol. The tactic is flexible and is not limited to carbenoids. Also, diverse carbanion-like species can act as nucleophiles, thus making it of general applicability.

Non-imidazole histamine H3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H3-antagonists with H1 blocking activities

New 2-(1-Piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazoles were prepared and tested as H1- and H3-receptor antagonists. A number of compounds showed weak H1-antagonistic activity, with pA2 values ranging from 5.5 to 6.1. The simple alkyl substituted, 2-[1-(4-methyl and 4-ethyl)piperazinyl] analogues show increasing, moderate H3-antagonistic activity (pA2=6.0, and pA2=7.0). The compounds with 4-phenylalkyl substitution, for both the piperazinyl and the hexahydro-1H-1,4-diazepin-1-yl homologues series, regardless of the different physicochemical properties of the para substituents at the phenyl ring, showed weak H3-antagonistic activity with pA2 values ranging from 4.4 to 5.6. Copyright (C) 1999 Elsevier Science S.A.

Structure of ω-Arylalkyl Radicals: A 13C CIDNP Investigation

Thermolysis of a series of ω-arylalkanoyl m-chlorobenzoyl (and acetyl) peroxides at ca. 100 deg C in cyclohexanone and in hexachloroacetone was studied by using 13C chemically induced dynamic nuclear polarization.Analysis of the observed 13C polarizations indicate that all the three radicals (β-arylethyl, γ-arylpropyl and δ-arylbutyl) have open-chain structures with no evidence for aryl participation resulting in spirocycloalkylcyclohexadienyl radicals.