2565-87-9 Usage
General Description
Phosphocitrate is a novel biochemical compound, consisting of a phosphorylated form of citrate, which has shown promising potential as a therapeutic agent in the treatment of various musculoskeletal disorders. Phosphocitrate has been found to inhibit the formation and growth of hydroxyapatite crystals that are responsible for the development of conditions such as osteoarthritis and kidney stone formation. Additionally, phosphocitrate has demonstrated anti-inflammatory and anti-catabolic properties, making it a potential candidate for the management of joint diseases and other related disorders. Its ability to modulate bone and cartilage metabolism, as well as its safety profile, make phosphocitrate a valuable target for further research and development in the field of musculoskeletal medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 2565-87-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,6 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2565-87:
(6*2)+(5*5)+(4*6)+(3*5)+(2*8)+(1*7)=99
99 % 10 = 9
So 2565-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H9O10P/c7-3(8)1-6(5(11)12,2-4(9)10)16-17(13,14)15/h1-2H2,(H,7,8)(H,9,10)(H,11,12)(H2,13,14,15)
2565-87-9Relevant articles and documents
A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterified derivatives
Turhanen, Petri A.,Demadis, Konstantinos D.,Peraeniemi, Sirpa,Vepsaelaeinen, Jouko J.
, p. 1468 - 1471 (2007)
(Chemical Equation Presented) A novel method for the synthesis of phosphocitrate (1, PC) starting from triethyl ester of citric acid and MeOPCl2 is described. The method is based on selective stepwise hydrolysis of ester moieties from the intermediate Me-O-P(O)(Cl)(Z) (Z = triethylcitrate), 4a, which also allows one to prepare partially esterified derivatives of PC with good yield and purity without chromatographic purifications.
CHEMICALLY MODIFIED PHOSPHOCITRATE AND ENTRAPMENT IN MICROPARTICLES FOR SUSTAINED INHIBITION OF BIOMINERALIZATION
Sallis, John,Meehan, John,Kamperman, Harold,Anderson, Maree
, p. 281 - 284 (2007/10/02)
Synthesis of glycolamide esters of phosphocitrate is described.Incorporation of salts or modified forms of phosphocitrate into albumin/polylactide based microspheres markedly improves efficiency in delivery.Strong inhibition of hydroxyapatite deposition into rat skin plaques was observed.