2565-87-9

Usage

Uses

Used in Musculoskeletal Medicine:
Phosphocitrate is used as a therapeutic agent for the treatment of various musculoskeletal disorders, such as osteoarthritis and kidney stone formation. It inhibits the formation and growth of hydroxyapatite crystals responsible for these conditions.
Used in Anti-Inflammatory and Anti-Catabolism Applications:
Phosphocitrate is used as an anti-inflammatory and anti-catabolic agent, demonstrating its potential in the management of joint diseases and other related disorders.
Used in Bone and Cartilage Metabolism Modulation:
Phosphocitrate is used to modulate bone and cartilage metabolism, contributing to its potential as a valuable target for further research and development in the field of musculoskeletal medicine. Its safety profile further enhances its potential for clinical applications.

InChI:InChI=1/C6H9O10P/c7-3(8)1-6(5(11)12,2-4(9)10)16-17(13,14)15/h1-2H2,(H,7,8)(H,9,10)(H,11,12)(H2,13,14,15)

Upstream product

• 73319-80-9 3-ethoxycarbonyl-3-phosphonooxypentanedioic acid diethyl ester 
• 151563-77-8 3-Carboxy-3-phosphonooxy-pentanedioic acid didiethylcarbamoylmethyl ester 
• 102089-54-3 2-diphenoxyphosphoryloxy-propane-1,2,3-tricarboxylic acid triethyl ester 
• 151563-78-9 3-Benzyloxycarbonyl-3-hydroxy-pentanedioic acid benzyl ester diethylcarbamoylmethyl ester 
• 161912-06-7 (4-Benzyloxycarbonylmethyl-2,2,2-trichloro-5-oxo-2λ⁵-[1,3,2]dioxaphospholan-4-yl)-acetic acid benzyl ester 
• 631-25-4 tribenzyl citrate 
• 77-93-0 citric acid triethyl ester 
• 929042-24-0 3-(chloro-methoxy-phosphanyloxy)-3-ethoxycarbonyl-pentanedioic acid diethyl ester 
• 929042-25-1 3-(chloromethoxyphosphoryloxy)-3-ethoxycarbonylpentanedioic acid diethyl ester 
• 161912-07-8 1,3-dibenzyl-2-phosphonooxy citrate 
• 151563-76-7 3-Carboxy-3-phosphonooxy-pentanedioic acid monodiethylcarbamoylmethyl ester 
• 151563-79-0 3-Benzyloxycarbonyl-3-hydroxy-pentanedioic acid didiethylcarbamoylmethyl ester 

Relevant academic research and scientific papers

A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterified derivatives

(Chemical Equation Presented) A novel method for the synthesis of phosphocitrate (1, PC) starting from triethyl ester of citric acid and MeOPCl2 is described. The method is based on selective stepwise hydrolysis of ester moieties from the intermediate Me-O-P(O)(Cl)(Z) (Z = triethylcitrate), 4a, which also allows one to prepare partially esterified derivatives of PC with good yield and purity without chromatographic purifications.

Synthesis via a cyclic dioxatrichlorophosphorane of 1,3-dibenzyl-2-phosphonooxy citrate

Phosphorylation of tribenzyl citrate with PCl5 proceeds via a cyclic dioxatrichlorophosphorane and results in the formation of 1,3-dibenzyl-2-phosphonooxy citrate. A mechanism for the phosphorylation and ester hydrolysis is proposed and the use

CHEMICALLY MODIFIED PHOSPHOCITRATE AND ENTRAPMENT IN MICROPARTICLES FOR SUSTAINED INHIBITION OF BIOMINERALIZATION

Synthesis of glycolamide esters of phosphocitrate is described.Incorporation of salts or modified forms of phosphocitrate into albumin/polylactide based microspheres markedly improves efficiency in delivery.Strong inhibition of hydroxyapatite deposition into rat skin plaques was observed.