256512-36-4

Upstream product

• 209917-53-3 4'-(methylamino)-N-(tert-butyl)[1,1'-biphenyl]-2-sulfonamide 
• 209917-95-3 1-(3-cyanophenyl)-3-methylpyrazol-5-yl carboxylic acid chloride 
• 82874-96-2 2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester 
• 209958-58-7 1-(3-cyanophenyl)-3-methyl-1H-pyrazol-5-ylcarboxylic acid 
• 209958-57-6 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 2881-99-4 3-cyano-phenylhydrazine hydrochloride 

Relevant academic research and scientific papers

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli