256512-42-2Relevant academic research and scientific papers
A short diastereoselective synthesis of 1-aminoindolo-[2,3-a]quinolizidines via an N-acyliminium ion cyclisation
Ducrot, Pierre,Thal, Claude
, p. 9037 - 9040 (1999)
trans 1-Aminoindolo[2,3-a]quinolizidines were synthesised using an intramolecular Pictet-Spengler-like reaction. Starting from commercially available N-Cbz-L-glutamic acid, indoloquinolizidines were obtained in only five steps with good yields. This improved synthesis is the result of both a highly regioselective imide reduction and a highly diastereoselective reaction using N-acyliminium ions.
