256639-37-9

Basic information

• Product Name: Methanone, (4-amino-6-methyl-3-cinnolinyl)(4-methylphenyl)-
• CAS NO: 256639-37-9
• Molecular Formula: C17H15N3O
• Molecular Weight: 277.326
• Mol File: 256639-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, (4-amino-6-methyl-3-cinnolinyl)(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-amino-6-methyl-3-cinnolinyl)(4-methylphenyl)-(256639-37-9)
• EPA Substance Registry System: Methanone, (4-amino-6-methyl-3-cinnolinyl)(4-methylphenyl)-(256639-37-9)

Safety Data

• Hazardous Substances Data: 256639-37-9(Hazardous Substances Data)

Upstream product

• 108-88-3 toluene 
• 40257-94-1 2-[2-(4-methylphenyl)hydrazono]malononitrile 
• 2028-84-4 p-methylbenzenediazonium chloride 

Downstream Products

• 256639-42-6 (4-diacetamido-6-methyl-cinnolin-3-yl)-p-tolyl-methanone 
• 256639-45-9 1,2-dihydro-9-methyl-4-(p-tolyl)-2-oxopyrido[3,2-c]cinnoline 

Relevant articles and documents

On the chemistry of cinnoline I. synthesis and reactions of (4-Amino-cinnolin-3-yl)-p-tolyl-methanones

The synthesis of a series of (4-Amino-cinnolin-3-yl)-p-tolyl-methanones from aryl-hydrazonomalononitrile in a one step procedure is reported. The (4-amino-cinnolin-3-yl)-p-tolyl-methanones could be annelated to the corresponding 1,2-dihydro-4-(p-tolyl)-2-oxopyrido[3,2-c]cinnoline derivatives via (4-acetamido-cinnolin-3-yl)-p-tolyl-methanones. Treatment of 1,2-dihydro-9-methyl-4-(p-tolyl)-pyrido[3,2-c]cinnoline-2-one with POCl1 and P2S5 gave 2-chloro-9-methyl-4-(p-tolyl)-pyrido[3,2-c]cinnoline and 1,2-dihydro-9-methyl-4-(p-tolyl)-pyrido[3,2-c]cinnoline-2-thione. Treatment of the ketone with malononitrile afforded 2-amino-3-cyano-9-methyl-4-(p-tolyl)-pyrido[3,2-c]cinnoline. Using these ketones, a facile and convenient route towards substituted pyrimidino[5,4-c]-cinnolines was developed. Chemical and spectroscopic evidences for the structures of the new compounds are presented.