2567-59-1

Usage

Uses

Used in Pharmaceutical Industry:
N,N-dibutyl-2-chloroacetamide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique chemical properties make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
N,N-dibutyl-2-chloroacetamide is used as a chemical intermediate in the synthesis of agrochemicals. Its mild antibacterial properties can be utilized in the development of pesticides and other agricultural products.
Used in Cosmetic and Personal Care Products:
N,N-dibutyl-2-chloroacetamide is used as a preservative or antimicrobial agent in cosmetic and personal care products. Its mild antibacterial properties help prevent the growth of bacteria and fungi, ensuring the safety and longevity of these products.
Used in Industrial Processes:
N,N-dibutyl-2-chloroacetamide is used as an additive in industrial processes to prevent the growth of bacteria and fungi. Its mild antibacterial properties make it a useful component in maintaining cleanliness and preventing contamination in various industrial applications.

Upstream product

• 111-92-2 dibutylamine 
• 79-04-9 chloroacetyl chloride 
• 22118-09-8 2-bromoacetyl chloride 
• 79-11-8 chloroacetic acid 
• 4015-58-1 monochloroacetic acid anhydride 

Downstream Products

• 79373-15-2 dibutyl-N,N-dibutylcarbamoylmethylphosphine oxide 
• 145290-28-4 N,N-Dibutyl-2-(di-p-tolyl-phosphinoyl)-acetamide 
• 145290-27-3 N,N-Dibutyl-2-(di-m-tolyl-phosphinoyl)-acetamide 
• 106231-57-6 Benzoic acid dibutylcarbamoylmethyl ester 
• 911289-85-5 2,2'-[2,3-naphthylenebis(oxy)]-bis(N,N-dibutyl(acetamide)) 
• 23784-57-8 dibutylamide of cinnamic acid 
• 107-84-6 1-chloro-3-methylbutane 
• 80413-41-8 oxide of diphenylphosphite 

Relevant academic research and scientific papers

Benzotriazole xanthate derivative lubricant additive and preparation method thereof

The invention discloses a benzotriazole xanthate derivative lubricant additive. According to the invention, the benzotriazole xanthate derivative lubricant additive is prepared according to the following steps: performing amidation on alkylamine and chloroacetyl chloride under the effect of alkali, thereby acquiring alkyl chloroacetamide; performing nucleophilic substitution reaction on benzotriazole, chloropropanol and carbon disulfide, thereby acquiring benzotriazole propyl xanthic sodium or potassium; performing nucleophilic substitution reaction on alkyl chloroacetamide and benzotriazole propyl xanthic sodium or potassium, thereby acquiring a compound with a general formula I. According to the invention, the preparation method is simple, the technical condition is mild, the raw materials are easily acquired, the compounding cost is low and the compounding yield is high. The benzotriazole xanthate derivative can be independently used as an extreme pressure wear-resistant anticorrosion additive of lubricating oil, also can be used together with the other lubricant additives, is capable of obviously promoting the carrying capacity of the base oil, greatly improving the wear-resistant antifriction performance of the base oil and effectively promoting the corrosion resistance of the base oil and is a biodegradable multifunctional lubricant additive.

Alkyl acetamidobenzotriazole derivative lubricating oil additive and preparation method thereof

The invention discloses a biodegradable alkyl acetamidobenzotriazole derivative lubricating oil additive which does not contain sulfur, phosphorus, halogens and metal elements as well as a preparation method and application thereof. The preparation method comprises the following steps: under the action of alkali, performing amidation on alkyl amine and chloroacetyl chloride to obtain alkyl chloroacetamide; and then performing a nucleophilic substitution reaction with benzotriazole to obtain a target compound of a formula I. The preparation method disclosed by the invention is simple in preparation method, mild in process condition, easily available in raw material, low in preparation cost and high in synthetic yield. The novel alkyl acetamidobenzotriazole derivative can be independently used as an extreme pressure anti-wear corrosion-resistant additive of lubricating oil, also can be used with other lubricating oil additives in a compound manner, also can be used in common working conditions and high-temperature working conditions, can improve the bearing capacity of basic oil obviously and improve the anti-wear performance, and is the lubricating oil additive which is environmentally friendly and multi-functional. The formula I is as shown in the specification.

Synthesis of berberine bromide analogs containing tertiary amides of acetic acid in the 9-O-position

9-O-Acetamide analogs of berberine bromide were prepared in 20-87% yields via reaction of the isoquinoline alkaloid berberrubine with tertiary amides of bromoacetic acid. Aminolysis did not occur during reaction of methyl-2-(9-demethoxyberberine bromide-9-yl)hydroxyacetate with secondary amines. The corresponding acid or its ethyl ester was isolated.

Synthesis, pharmacology and?molecular modeling of?N-substituted 2-phenyl-indoles and?benzimidazoles as?potent GABAA agonists

Among the known non-benzodiazepine hypnotic drugs, Zolpidem (1a), Indiplon (2a) and Zaleplon (2b) have shown high affinity and selectivity for the α1 subunit of the GABA-A receptor. Our group has performed pharmacophoric and ADMET-prediction studies to evaluate a virtual library of new molecules based on privileged structures. Among these, we have synthesized a library of N-substituted indoles and a library of N-substituted benzimidazoles. Afterwards, in vitro screening and in vivo spontaneous motor activity in mice has revealed molecules with good in vitro affinities for the α1 receptor and potent in vivo induction of sedation.

"Crowned" Fe4S4 Clusters as Electrochemical Metal Ion Sensors

A series of Fe4S4 cluster compounds I, III, and V, in which the cuboidal cluster core is appended with four crown ether thiolate ligands, and II and IV, bearing thiolate ligands without crown ether parts, has been synthesized and characterized. The spectroscopic and electrochemical properties of these compounds are determined by the electronic nature of the thiolate ligands. Only in the case of III, where a very short α-thioacetyl linker was used to connect the crown ether ligands to the cluster core, was a restricted conformational freedom of the ligand observed. A detailed electrochemical study of the influence of alkali and earth alkali metal ions (Li+, Na+, K+, Mg2+, and Ba2+) on the reversible 2-/3- reduction of the cluster compounds was performed. In the case of the crown ether appended clusters I,III, and V, the addition of these metal ions resulted in an anodic shift, i.e. in positive direction, of the reduction potential (modulation effect) and to larger current responses (promotion effect). The magnitude of the modulation effects is determined by the binding affinity of the metal ions in the crown ether ligands, and by the distance between bound metal ions and the redox active cluster core. Variation of the linker between the cluster core and the metal ion binding site resulted in cluster compounds with almost inverse selectivities for e.g. K+ and Ba2+ in the case of I and III. For the large effects found for compound I a lariat binding mode is proposed.

A general method for the synthesis of N,N-dialkylaminobutylamines

A general method for the synthesis of N,N-dialkylaminobutylamines 4 from readily available chloroacetamides 6 is described.

Selective cation binding with cis,cis-1,3,5-trioxycyclohexyl based ligands: application to ion transport and electrochemical detection and assessment of complexation by electrospray mass spectrometry

The synthesis is reported of two sets of oxa-amide ionophores based on 2-phenylglycerol and cis,cis-cyclohexane-1,3,5-triol, with ligand coordination numbers of four, five and six.Ionophores based on the hexadentate cyclohexyl triamide 9 show excellent Na+/K+ selectivity (-logKpotNa,K=3.1), and the pentadentate analogue 10 shows good L+/Na+ selectivity (-logKpotLi,Na=2.2).Solution NMR and liquid-liquid extraction studied confirmed the formation of 1:1 complexes and IR studies pinpointed the presence of amide binding.Ligands based on 2-phenylglycerol exhibited good Ca2+ selectivity which was highest for the hexadentate triamide, 6.Detailed ESMS studies revealed similar trends in ion-binding, performed under controlled conditions.

Synthesis of Dibenzocrown Ethers with Pendent Amide Groups

Synthetic routes to twenty six crown ether compounds with pendent amide, N-alkylamide, or N,N-dialkylamide groups are reported.The new crown ether compounds are based on sym-dibenzo-16-crown-5-oxyacetamide and sym-(propyl)-dibenzo-16-crown-5-oxyacetamide and are obtained in high yields.

Heterocyclic diamides and method for improving feed utilization and lactation in ruminant animals

Novel diamides having a nitrogen-containing heterocyclic moiety such as pyridyl are disclosed that are useful for improving feed utilization efficiency of ruminants and for improving lactation of lactating ruminants.