2567-85-3

Basic information

• Product Name: Benzenesulfonic acid,4-methyl-, 2-cyclooctylidenehydrazide
• Synonyms: Benzenesulfonicacid, 4-methyl-, cyclooctylidenehydrazide (9CI); p-Toluenesulfonic acid,cyclooctylidenehydrazide (7CI,8CI); Cyclooctanone tosylhydrazone; NSC 117506
• CAS NO: 2567-85-3
• Molecular Formula: C15H22 N2 O2 S
• Molecular Weight: 294.418
• Mol File: 2567-85-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 442.7°Cat760mmHg
• Flash Point: 221.5°C
• Density: 1.19g/cm³
• CAS DataBase Reference: Benzenesulfonic acid,4-methyl-, 2-cyclooctylidenehydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid,4-methyl-, 2-cyclooctylidenehydrazide(2567-85-3)
• EPA Substance Registry System: Benzenesulfonic acid,4-methyl-, 2-cyclooctylidenehydrazide(2567-85-3)

Safety Data

• Hazardous Substances Data: 2567-85-3(Hazardous Substances Data)

Upstream product

• 502-49-8 cycloactanone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 292-64-8 Cyclooctan 
• 1445871-62-4 C₂₁H₂₃NO₂ 
• 931-88-4 1,2-cyclooctene 
• 448211-45-8 (Z)-2-(cyclooct-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 448211-45-8 2-(cyclooct-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 96308-48-4 cyclooctene-1-carbaldehyde 
• 6038-12-6 cyclooctene-1-carboxaldehyde 
• 53867-57-5 1,2-dicyclooctylidenehydrazine 

Relevant articles and documents

Copper-catalyzed tri- or tetrafunctionalization of alkenylboronic acids to prepare tetrahydrocarbazol-1-ones and indolo[2,3-a]carbazoles

We describe a cascade strategy for tri- or tetrafunctionalization of alkenylboronic acids to prepare diverse tetrahydrocarbazol-1-ones and indolo[2,3-a]carbazoles in good yields withN-hydroxybenzotriazin-4-one (HOOBT) and arylhydrazines as oxygen and nitrogen sources, respectively. Mechanistic studies reveal that the domino reaction undergoes the copper-catalyzed Chan-Lam reaction, [2,3]-rearrangement, nucleophilic substitution, oxidation and sequential [3,3]-rearrangement over five steps in a one-pot reaction. The reaction shows a broad substrate scope and tolerates a wide range of functional groups. More importantly, the reaction is easily performed at gram scales and the product is purified by simple extraction, washing, and recrystallization without flash column chromatography. The present protocol features easily available starting materials, high site-marked functionalization, five-step cascade in one pot, multiple C-C/C-O/C-N bond formation, and diversity of indole motifs.

One-Pot Synthesis of Spirocyclic or Fused Pyrazoles from Cyclic Ketones: Calcium Carbide as the Carbon Source in Ring Expansion

N-Tosylhydrazones generated in situ from cyclic ketones smoothly underwent a [3 + 2] cycloaddition to afford saturated spirocyclic pyrazoles and further transformed to the fused analogues via a ring expansion in certain cases. An inexpensive and renewable

Catalytic three-component one-pot reaction of hydrazones, dihaloarenes, and amines

A new three-component assembly reaction between N-tosylhydrazones, dihalogenated arenes, and various primary and secondary amines was devised, producing nitrogen-containing 1,1'-diarylethylenes in good yields. The two C-C and C-N bonds formed through this