256922-53-9

Usage

Uses

Given the limited information provided, the following potential uses are speculative based on the compound's structure and typical applications of similar organic compounds in the fields of pharmacology and biochemistry:
Used in Pharmaceutical Industry:
2-Propylthiazolo[4,5-c]quinolin-4-amine could be used as a pharmaceutical intermediate for the synthesis of drugs targeting various diseases. Its unique structure may allow it to interact with specific biological targets, such as enzymes or receptors, thereby modulating their activity for therapeutic purposes.
Used in Biochemical Research:
In the field of biochemistry, 2-Propylthiazolo[4,5-c]quinolin-4-amine might serve as a research tool to study the interactions between small molecules and biological macromolecules. Its heterocyclic and aromatic sections could facilitate the investigation of molecular recognition processes and the development of new biochemical assays.
Used in Drug Design and Development:
2-Propylthiazolo[4,5-c]quinolin-4-aMine's potential use in drug design and development could involve its application as a lead compound for the creation of new pharmaceuticals. Its structural features may provide a foundation for the optimization of drug candidates with improved potency, selectivity, and pharmacokinetic properties.

Upstream product

• 256922-90-4 2-propylthiazolo[4,5-c]quinoline 5-oxide 
• 50332-66-6 3-nitro-quinolin-4-ol 
• 121845-92-9 2-<2-nitroethylideneamino>benzoic acid 
• 111199-35-0 2-propylthiazolo[4,5-c]quinoline 
• 1421771-74-5 N-(4-hydroxyquinolin-3-yl)butyramide 
• 99512-72-8 3-amino-4-hydroxyquinoline 
• 3019-71-4 Trichloroacetyl isocyanate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1421771-41-6 C₁₇H₂₁N₃S 
• 1421771-44-9 C₁₄H₁₃N₃OS 
• 1421771-48-3 C₂₉H₄₃N₃OS 
• 1421771-49-4 C₂₀H₁₇N₃OS 
• 1421771-50-7 C₁₅H₁₄N₆OS 
• 1421771-51-8 C₁₆H₁₆N₆OS 
• 1421771-52-9 C₁₈H₁₇N₃OS 
• 1421771-45-0 C₁₅H₁₅N₃OS 
• 1421771-53-0 C₁₅H₁₅N₃O₂S 
• 1421771-54-1 C₁₆H₁₇N₃O₂S 
• 1421771-55-2 C₁₈H₂₁N₃O₂S 
• 1421771-56-3 C₂₂H₂₉N₃O₂S 
• 1421771-57-4 C₁₄H₁₄N₄OS 
• 1421771-58-5 C₁₄H₁₅N₃O₂S₂ 

Relevant academic research and scientific papers

Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines

Toll-like receptor (TLR)-8 agonists typified by the 2-alkylthiazolo[4,5-c] quinolin-4-amine (CL075) chemotype are uniquely potent in activating adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds could be promising candidate vaccine adjuvants, especially for neonatal vaccines. Alkylthiazoloquinolines with methyl, ethyl, propyl and butyl groups at C2 displayed comparable TLR8-agonistic potencies; activity diminished precipitously in the C2-pentyl compound, and higher homologues were inactive. The C2-butyl compound was unique in possessing substantial TLR7-agonistic activity. Analogues with branched alkyl groups at C2 displayed poor tolerance of terminal steric bulk. Virtually all modifications at C8 led to abrogation of agonistic activity. Alkylation on the C4-amine was not tolerated, whereas N-acyl analogues with short acyl groups (other than acetyl) retained TLR8 agonistic activity, but were substantially less water-soluble. Immunization in rabbits with a model subunit antigen adjuvanted with the lead C2-butyl thiazoloquinoline showed enhancements of antigen-specific antibody titers.

Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.