256934-83-5

Basic information

• Product Name: 1-Methyl-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydrooxazol-2-yl]-1H-indole
• Synonyms: A-259745
• CAS NO: 256934-83-5
• Molecular Formula: C₂₁H₂₂N₂O₄
• Molecular Weight: 366.42049
• Mol File: 256934-83-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Methyl-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydrooxazol-2-yl]-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydrooxazol-2-yl]-1H-indole(256934-83-5)
• EPA Substance Registry System: 1-Methyl-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydrooxazol-2-yl]-1H-indole(256934-83-5)

Safety Data

• Hazardous Substances Data: 256934-83-5(Hazardous Substances Data)

Upstream product

• 256935-67-8 (1S)-2-azido-1-(3,4,5-trimethoxyphenyl)ethanol 
• 177329-70-3 (S)-1-(3,4,5-trimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethanol 
• 177329-69-0 (S)-1-(3,4,5-trimethoxyphenyl)-1,2-ethanediol 
• 13400-02-7 3,4,5-trimethoxy styrene 
• 91634-11-6 N-methyl-5-cyanoindole 
• 256935-68-9 (1S)-2-amino-1-(3,4,5-trimethoxyphenyl)ethanol 
• 186129-25-9 1-methyl-1H-indole-5-carboxylic acid 
• 128742-76-7 methyl 1-methyl-1H-indole-5-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of 2-Indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent

A series of indole containing oxazolines has been discovered as a result of structural modifications of the lead compound A-105972. The compounds exert their anticancer activity through inhibition of tubulin polymerization by binding at the colchicine site. A-289099 was identified as an orally active antimitotic agent active against various cancer cell lines including those that express the MDR phenotype. The anticancer activity, pharmacokinetics, and an efficient and enantioselective synthesis of A-289099 are described.