256935-85-0

Usage

Uses

Used in Organic Synthesis:
Methyl 4-amino-2-chloro-5-iodobenzoate is used as a building block in organic synthesis for the production of various chemical compounds.
Used in Pharmaceutical Industry:
Methyl 4-amino-2-chloro-5-iodobenzoate is used as a precursor in the production of pharmaceuticals due to its structural features and chemical reactivity.
Used in Agrochemical Industry:
Methyl 4-amino-2-chloro-5-iodobenzoate is used as a building block in the production of agrochemicals.
Used in Medicinal Chemistry and Drug Discovery:
Methyl 4-amino-2-chloro-5-iodobenzoate is used as a potential candidate in medicinal chemistry and drug discovery due to its structural features and chemical reactivity.

Upstream product

• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 935676-16-7 2-chloro-4-[N'-(1-ethoxycarbonyl-ethylidene)-hydrazino]-5-iodo-benzoic acid methyl ester 

Downstream Products

• 162100-83-6 6-chloro-1H-indole-5-carboxylic acid methyl ester 
• 1613730-16-7 methyl 4-amino-2-chloro-5-isobutylbenzoate 
• 1613730-22-5 methyl 4-amino-2-chloro-5-(3-methoxyprop-1-yn-1-yl)benzoate 
• 1616257-23-8 methyl 4-amino-2-chloro-5-(2-ethoxyvinyl)benzoate 
• 1613730-17-8 methyl 4-amino-2-chloro-3-iodo-5-isobutylbenzoate 
• 1613730-18-9 methyl 4-amino-2-chloro-5-isobutyl-3-((trimethylsilyl)ethynyl)benzoate 
• 1613730-23-6 methyl 4-amino-2-chloro-5-(3-methoxypropyl)benzoate 
• 1613730-24-7 methyl 4-amino-2-chloro-3-iodo-5-(3-methoxypropyl)benzoate 
• 1613730-25-8 methyl 4-amino-2-chloro-5-(3-methoxypropyl)-3-((trimethylsilyl)ethynyl)benzoate 
• 1616257-24-9 methyl 4-amino-2-chloro-5-(2-ethoxyethyl)benzoate 
• 1616257-25-0 methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-iodobenzoate 
• 1616257-26-1 methyl 4-amino-2-chloro-5-(2-ethoxyethyl)-3-((trimethylsilyl)ethynyl)benzoate 
• 1613730-08-7 methyl 2-chloro-4-hydrazinyl-5-iodobenzoate 

Relevant academic research and scientific papers

HERBICIDAL COMPOUNDS

The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A1a, A1b, R1, R2, R3 and R4 and R5 are as defined herein.

TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY

The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treat

INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.

OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.

AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula

Utility of Japp-Klingemann reaction for the preparation of 5-carboxy-6-chloroindole via Fischer indole protocol

5-Carboxy-6-chloroindole, a precursor for p38 kinase inhibitor, was prepared from 4-amino-2-chloro-3-iodobenzoicacid by following the Japp-Klingemann synthetic approach. The structures of the key intermediates were also confirmed by X-ray analyses. Computational analysis was helpful in understanding the importance of the substituents at the cyclization step of the synthesis.

Indole-type derivatives as inhibitors of p38 kinase

The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.

Oxazoline antiproliferative agents

Compounds having Formula I are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.