256949-49-2Relevant articles and documents
Diastereo- and enantioselective synthesis of N,O-nucleosides
Chiacchio, Ugo,Corsaro, Antonino,Iannazzo, Daniela,Piperno, Anna,Pistara, Venerando,Rescifina, Antonio,Romeo, Roberto,Sindona, Giovanni,Romeo, Giovanni
, p. 2717 - 2723 (2007/10/03)
The diastereo- and enantioselective synthesis of α- and β-3′-hydroxymethyl-N,O-nucleosides is described, based on the 1,3-dipolar cycloaddition of a N-glycosyl nitrone. Two approaches have been evaluated: the one-step procedure, which uses vinyl nucleobases, showed a better stereoselectivity towards β-nucleosides.