256950-42-2

Upstream product

• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 62-55-5 thioacetamide 

Downstream Products

• 477339-82-5 4-(3,4-dimethoxyphenyl)-5-(6-methoxypyrid-3-yl)-2-methylthiazole 
• 477339-79-0 4-(3,4-dimethoxyphenyl)-2-methyl-5-(3-thienyl)thiazole 
• 477339-78-9 4-(3,4-dimethoxyphenyl)-5-(3-furyl)-2-methylthiazole 
• 361576-85-4 4-(3,4-dimethoxyphenyl)-5-(6-methoxypyrid-2-yl)-2-methylthiazole 
• 361576-84-3 4-(3,4-dimethoxyphenyl)-2-methyl-5-(2-thienyl)thiazole 
• 361576-83-2 4-(3,4-dimethoxyphenyl)-5-(2-furyl)-2-methylthiazole 
• 477339-77-8 5-bromo-4-(3,4-dimethoxyphenyl)-2-methylthiazole 

Relevant academic research and scientific papers

Computer-Assisted Selective Optimization of Side-Activities—from Cinalukast to a PPARα Modulator

Automated computational analogue design and scoring can speed up hit-to-lead optimization and appears particularly promising in selective optimization of side-activities (SOSA) where possible analogue diversity is confined. Probing this concept, we employ

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Methionine aminopeptidase (MetAP) is a promising target to develop novel antibiotics, because all bacteria express MetAP from a single gene that carries out the essential function of removing N-terminal methionine from nascent proteins. Divalent metal ion

A simple route to new phenanthro- and phenanthroid-fused thiazoles by a PIFA-mediated (hetero)biaryl coupling reaction

An application of the PIFA-mediated [PIFA: phenyliodine(III) bis(trifluoroacetate) biaryl coupling reaction is presented and extended to the formation of heterobiaryl connections. A preliminary study of the scope and limitations of this procedure was carried out in the synthesis of phenanthroids 11 from a series of phenethyl-substituted heterocycles 10, It was observed that in some cases a competitive dimerization process took place. It was also found that the coupling step could be efficiently extended to a larger number of examples if an aromatic ring were situated fused to the 1,2-diarylethane skeleton, as in 23 and 30. The synthesis of a series of 4,5-diarylthiazoles 23a-g was therefore carried out to explore the electronic requirements and the regioselectivity of the PIFA-mediated non-phenolic coupling reaction. When the same procedure was applied to aryl-heteroarylthiazoles 30, a series of phenanthroid-fused thiazoles 31 was obtained in good overall yields. To the best of our knowledge, no oxidative aryl-heteroaryl coupling reaction of this type had previously been reported. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.