256951-73-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Piperidyl)benzenecarbonitrile hydrochloride is used as a precursor for the synthesis of various drugs targeting the central nervous system due to its versatile pharmacological properties.
Used in Treatment of Depression:
2-(4-Piperidyl)benzenecarbonitrile hydrochloride is used as a selective serotonin reuptake inhibitor for the treatment of depression, helping to increase the availability of serotonin in the brain and alleviate depressive symptoms.
Used in Treatment of Anxiety:
2-(4-Piperidyl)benzenecarbonitrile hydrochloride is used as a potential therapeutic agent for the treatment of anxiety disorders, leveraging its action as a selective serotonin reuptake inhibitor to regulate mood and reduce anxiety levels.
Used in Treatment of Neuropathic Pain:
2-(4-Piperidyl)benzenecarbonitrile hydrochloride is used as a potential treatment for neuropathic pain, which may be attributed to its pharmacological properties and its ability to modulate neurotransmitter levels in the central nervous system.
Used in Drug Development Research:
2-(4-Piperidyl)benzenecarbonitrile hydrochloride is used as a research compound for investigating its potential as a nicotinic acetylcholine receptor antagonist, which could lead to the development of new drugs targeting cognitive disorders and other conditions related to the cholinergic system.

Upstream product

• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 194669-38-0 2-[1-tert-butoxycarbonyl-(1.2.3.6-tetrahydropyridin-4-yl)]benzonitrile 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 256951-72-1 tert-butyl 4-(2-cyanophenyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Oxazolidinones useful as alpha 1A adrenoceptor antagonists

Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

Oxazolidinones useful as alpha 1a adrenoceptor antagonists

Novel hydroxymethyl- and alkoxymethyl-oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

Dihydropyridinones and pyrrolinones useful as alpha 1A adrenoceptor antagonists

Novel dihydropyridinone and pyrrolinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha1aadrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha1areceptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

In vitro, and in vivo, evaluation of dihydropyrimidinone C-5 amides as potent and selective α(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

α1 Adrenergic receptors mediate both vascular and lower urinary tract tone, and α1 receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign prostatic hyperplasia (BPH). Recently, three different subtypes of this receptor have been identified, with the α(1A) receptor being most prevalent in lower urinary tract tissue. This paper explores 4-aryldihydropyrimidinones attached to an aminopropyl-4- arylpiperidine via a C-5 amide as selective α(1A) receptor subtype antagonists. In receptor binding assays, these types of compounds generally display K(i) values for the α(1a) receptor subtype 20%) and half-life (>6 h) in both rats and dogs. Due to its selectivity for the α(1a) over the α(1b) and α(1d) receptors as well as its favorable pharmacokinetic profile, 48 has the potential to relieve the symptoms of BPH without eliciting effects on the cardiovascular system.

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.

A series of alpha1a receptor antagonists derived from a 4-aryl-3,4-dihydropyridine-2-one heterocycle is disclosed. Potency in the low nanomolar to picomolar range along with high selectivity was obtained. In vivo efficacy in a prostate contraction model in rats was observed with a few derivatives.