256954-24-2

Upstream product

• 762-49-2 2-fluoroethyl bromide 
• 256954-22-0 ethyl 4-benzoyloxy-6-fluoro-2-mercapto-7-(4-trifluoroacetylaminophenyl)quinoline-3-carboxylate 
• 98-88-4 benzoyl chloride 
• 256954-20-8 ethyl 4-benzoyloxy-6-fluoro-2-(methoxymethylthio)-7-(4-trifluoroacetylaminophenyl)quinoline-3-carboxylate 

Downstream Products

• 166380-63-8 ethyl 6-fluoro-1-fluoromethyl-4-oxo-7-(4-trifluoroacetylaminophenyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 
• 256954-25-3 ethyl 4-benzoyloxy-2-(1-chloro-2-fluoroethylthio)-6-fluoro-7-[4-(trifluoroacetylamino)phenyl]quinoline-3-carboxylate 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of novel 7-substituted 6-fluoro-1- methylene-4-oxo-4H-[1,3]-thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives

A series of 7-substituted 6-fluoro-1-methylene-4-oxo-4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives (2) and (3) was prepared and evaluated for antibacterial activity. These compounds were obtained by the treatment of the 1-methanesulfonyloxymethyl or 1-fluoromethyl thiazetoquinolone-3-carboxylates (12, 14 and 20) with potassium hydroxide. Compounds (2) and (3) showed excellent in vitro antibacterial activity against both gram-negative and gram-positive bacteria including quinolone and Methicillin-resistant Staphylococcus aureus.