25698-44-6

Usage

Uses

Used in Pharmaceutical Industry:
(R)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID is used as a key intermediate in the synthesis of pharmaceutical drugs for various medical conditions. Its unique structure allows for the development of novel drug candidates with improved efficacy and selectivity.
Used in Organic Chemistry:
(R)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID serves as a building block in organic chemistry, enabling the creation of new compounds with diverse applications. Its presence in various chemical reactions and mechanisms makes it an important subject of study for chemists.
Used in Drug Development:
(R)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID is used as a starting material in the development of new therapies for various medical conditions. Its unique properties and reactivity contribute to the discovery of innovative treatments and medications.
Used in Research and Development:
(R)-AMINO-(3-FLUORO-PHENYL)-ACETIC ACID is employed in research and development efforts to study chemical reactions and mechanisms. Its involvement in various processes helps scientists better understand the underlying principles and develop new methodologies in the field of chemistry.

Upstream product

• 32222-47-2 2-(3-fluorophenyl)-2-hydroxyacetic acid 
• 350-51-6 3-fluorostyrene 

Relevant academic research and scientific papers

One-Pot Enantioselective Synthesis of d-Phenylglycines from Racemic Mandelic Acids, Styrenes, or Biobased l-Phenylalanine via Cascade Biocatalysis

Enantiopure d-phenylglycine and its derivatives are an important group of chiral amino acids with broad applications in thepharmaceutical industry. However, the existing synthetic methods for d-phenylglycine mainly rely on toxic cyanide chemistry and multistep processes. To provide green and safe alternatives, we envisaged cascade biocatalysis for the one-pot synthesis of d-phenylglycine from racemic mandelic acid, styrene, and biobased l-phenylalanine, respectively. Recombinant Escherichia coli (LZ110) was engineered to coexpress four enzymes to catalyze a 3-step reaction in one pot, transforming mandelic acid (210 mM) to give enantiopure d-phenylglycine in 29.5 g L?1 (195 mM) with 93% conversion. Using the same whole-cell catalyst, twelve other d-phenylglycine derivatives were also produced from the corresponding mandelic acid derivatives in high conversion (58–94%) and very high ee (93–99%). E. coli (LZ116) expressing seven enzymes was constructed for the transformation of styrene to enantiopure d-phenylglycine in 80% conversion via a one-pot 6-step cascade biotransformation. Twelve substituted d-phenylglycines were also produced from the corresponding styrene derivatives in high conversion (45–90%) and very high ee (92–99%) via the same cascade reactions. A nine-enzymeexpressing E. coli (LZ143) was engineered to transform biobased l-phenylalanine to enantiopure d-phenylglycine in 83% conversion via a one-pot 8-step transformation. Preparative biotransformations were also demonstrated. The high-yielding synthetic methods use cheap and green reagents (ammonia, glucose, and/or oxygen), and E. coli whole-cell catalysts, thus providing green and useful alternative methods for manufacturing d-phenylglycine. (Figure presented.).