25699-82-5

Usage

Uses

Used in Pharmaceutical Industry:
3-(1H-Pyrazol-1-yl)benzonitrile is used as a precursor for the synthesis of various pharmaceuticals due to its ability to be incorporated into the molecular structures of potential drugs. Its unique chemical properties and the presence of the pyrazole ring contribute to its utility in creating new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(1H-Pyrazol-1-yl)benzonitrile serves as a key intermediate in the development of agrochemicals, such as pesticides and herbicides. Its structural features allow for the creation of compounds that can effectively target and control agricultural pests and weeds.
Used in Organic Synthesis:
3-(1H-Pyrazol-1-yl)benzonitrile is utilized as a versatile intermediate in organic synthesis for the preparation of a wide range of chemical compounds. Its reactivity and structural attributes make it suitable for various synthetic pathways, facilitating the creation of complex organic molecules.
Used in Medicinal Chemistry Research:
3-(1H-Pyrazol-1-yl)benzonitrile is employed as a subject of interest in medicinal chemistry research. The pyrazole moiety may endow the compound with pharmacological properties, making it a candidate for further investigation into its potential therapeutic applications and mechanisms of action.

InChI:InChI=1/C10H7N3/c11-8-9-3-1-4-10(7-9)13-6-2-5-12-13/h1-7H

Upstream product

• 288-13-1 NH-pyrazole 
• 69113-59-3 3-iodobenzonitrile 
• 25688-18-0 1-(3-nitrophenyl)-1H-pyrazole 
• 766-84-7 3-chloro-benzonitrile 
• 2237-30-1 m-cyanoaniline 
• 619-27-2 3-nitrophenylhydrazine 
• 544-92-3 copper(I) cyanide 
• 151-50-8 potassium cyanide 
• 184097-88-9 3-(1H-pyrazol-1-yl)aniline 

Downstream Products

• 935460-37-0 1-(3-(1H-pyrazol-1-yl)phenyl)-2-ethylcyclopropanamine 
• 352196-01-1 2,4,6-tris(3-(1H-pyrazol-1-yl)phenyl)-1,3,5-triazine 

Relevant academic research and scientific papers

L -(-) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

l-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

Copper-catalyzed arylation of nitrogen heterocycles from anilines under ligand-free conditions

The arylation of pyrazole and derivatives can be achieved by coupling arenediazonium species (formed in situ from anilines) by using a catalytic system that employs low-toxicity and inexpensive copper metal under very mild and ligand-free conditions (T = 20 ° C). From other nitrogen heterocycles, the presence of an additive (NBu4I) significantly improves the efficiency of the catalytic system. These results represent the first examples of C-N bond formation from arenediazonium species.

An Ullmann coupling of aryl iodides and amines using an air-stable diazaphospholane ligand

(Chemical Equation Presented) A copper-based catalytic system, using an air-stable diazaphospholane as the ligand, was developed for an efficient Ullmann reaction between aryl iodides and alkyl or heterocyclic amines.

Solvent-free preparation of tris-pyrazolyl-1,3,5-triazines

Tris-pyrazolyl-1,3,5-triazines have been prepared by cyclotrimerization of aromatic nitriles in solvent-free conditions. The interesting structures of these compounds make them candidates for application in coordination chemistry and crystal engineering.