25712-16-7Relevant academic research and scientific papers
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors
Vaisburg, Arkadii,Paquin, Isabelle,Bernstein, Naomy,Frechette, Sylvie,Gaudette, Frederic,Leit, Silvana,Moradei, Oscar,Raeppel, Stephane,Zhou, Nancy,Bouchain, Giliane,Woo, Soon Hyung,Jin, Zhiyun,Gillespie, Jeff,Wang, James,Fournel, Marielle,Yan, Pu Theresa,Trachy-Bourget, Marie-Claude,Robert, Marie-France,Lu, Aihua,Yuk, Jimmy,Rahil, Jubrail,MacLeod, A. Robert,Besterman, Jeffrey M.,Li, Zuomei,Delorme, Daniel
, p. 6729 - 6733 (2008/03/18)
A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.
Organosilicon synthesis of isocyanates: I. Synthesis of isocyanates of the furan, thiophene, and mono-and polyfluorophenyl series
Lebedev,Lebedeva,Sheludyakov,Ovcharuk,Kovaleva,Ustinova
, p. 110 - 115 (2008/01/27)
A convenient synthesis of known and unknown isocyanates of the furan, thiophene, and mono-and polyfluorophenyl series, involving silylation of starting amines with hexamethyldisilazane or chlorotrimethylsilane, followed by phosgenation of the resulting N-silyl-substituted amines. An unusual high-temperature rearrangement of 3-(methoxycarbonyl)-4,5-dimethylthiophene-2-yl isocyanate into its 5-ethyl isomer. ortho-Fluorine substituent in anilines decreases the yield of isocyanates, whereas 2,3,5,6-tetrafluorophenyl isocyanate exists for only a short time as a 5% toluene solution. Pleiades Publishing, Inc. 2006.
Heterocyclic dihydrazole compounds and their use for controlling fungal plant diseases
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, (2008/06/13)
PCT No. PCT/US96/06533 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed May 8, 1996 PCT Pub. No. WO96/36633 PCT Pub. Date Nov. 21, 1996Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which ar
