25717-80-0 Usage
Chemical Properties
White to Off-White Solid
Originator
Corvasal,Hoechst
Uses
Different sources of media describe the Uses of 25717-80-0 differently. You can refer to the following data:
1. Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitr
ic oxide donor.
2. Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.
Manufacturing Process
1.6 parts by volume of ethyl chloroformate is stirred dropwise into a
suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in
5 parts by volume of pyridine, and the mixture is agitated for a while to allow
reaction to take place. Pyridine is removed from the reaction mixture by
evaporation, and the residue is dissolved in a small amount of water and
extracted with chloroform several times. The extract is dehydrated by adding
anhydrous magnesium sulfate and subjected to filtration. Chloroform is
removed from the filtrate by distillation, crude crystals being obtained.
Recrystallization of the crude crystals from toluene gives 0.6 part by weight of
3-morpholino-N-carboethoxysydnonimine having a melting point of 140°-
141°C. Yield 51%.
Brand name
Corvaton (Hoechst-Roussel).
Therapeutic Function
Coronary vasodilator
Check Digit Verification of cas no
The CAS Registry Mumber 25717-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,7,1 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25717-80:
(7*2)+(6*5)+(5*7)+(4*1)+(3*7)+(2*8)+(1*0)=120
120 % 10 = 0
So 25717-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3
25717-80-0Relevant articles and documents
Anionic N-heterocyclic carbenes derived from sydnone imines such as molsidomine. Trapping reactions with selenium, palladium, and gold
Freese, Tyll,Lücke, Ana-Luiza,Schmidt, Catharina A.S.,Polamo, Mika,Nieger, Martin,Namyslo, Jan C.,Schmidt, Andreas
, p. 5350 - 5357 (2017/08/11)
The sydnone imines Molsidomine and 5-(benzoylimino)-3-(2-methoxyphenyl)-1,2,3-oxadiazolium-2-ide gave anionic N-heterocyclic carbenes on deprotonation at C4 which were trapped as methylated selenium adducts, gold complexes (X-ray analysis) as well as palladium complexes (X-ray analysis). The 13C NMR resonance frequencies of the carbene carbon atom are extremely shifted upfield and appear at δ = 142.1 ppm (Molsidomine carbene) and δ = 159.8 ppm (sydnone imine carbene). The Pd complexes were applied as catalysts in Suzuki-Miyaura and Sonogashira-Hagihara cross-coupling reactions.