2572-44-3

Basic information

• Product Name: AKOS BBS-00005393
• Synonyms: AKOS BBS-00005393;ASISCHEM C58329;6-Chloro-N,N'-bis(4-chlorophenyl)-1,3,5-triazine-2,4-diamine;[4-chloro-6-[(4-chlorophenyl)amino]-s-triazin-2-yl]-(4-chlorophenyl)amine;2-CHLORO-4,6-BIS(P-CHLOROANILINO)-S-TRIAZINE;STK035676;ZINC02278353
• CAS NO: 2572-44-3
• Molecular Formula: C₁₅H₁₀Cl₃N₅
• Molecular Weight: 366.63
• Mol File: 2572-44-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 223 °C
• Boiling Point: 555.9°Cat760mmHg
• Flash Point: 290°C
• Appearance: /
• Density: 1.546g/cm³
• PKA: 2.57±0.10(Predicted)
• CAS DataBase Reference: AKOS BBS-00005393(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BBS-00005393(2572-44-3)
• EPA Substance Registry System: AKOS BBS-00005393(2572-44-3)

Safety Data

• Hazardous Substances Data: 2572-44-3(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 

Downstream Products

• 1450982-27-0 N²,N⁴-bis(4-chlorophenyl)-6-(4-(2-((7-chloroquinolin-4-yl)amino)-ethyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine 
• 1620172-72-6 5-(4-chloro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-chlorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-71-5 5-(2-chloro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-chlorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-70-4 5-(4-nitro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-chlorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-69-1 5-(2-nitro-phenyl)-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-chlorophenylamino)-[1,3,5]triazin-2-yl]-amide 
• 1620172-68-0 3,5-diphenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4,6-bis-(4-chloro-phenylamino)-[1,3,5]triazin-2-yl]-amide 
• 942045-94-5 N²,N⁴-bis(4-chlorophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine 
• 1453805-42-9 4-(4,6-bis(4-chlorophenylamino)-1,3,5-triazin-2-yl)-N-(7-chloroquinolin-4-yl)piperazine-1-carbothioamide 
• 1408322-20-2 C₂₈H₂₄Cl₂N₁₀S₂ 
• 1258254-44-2 C₂₄H₁₆Cl₂N₈O₂S 
• 1084910-17-7 C₂₃H₁₈Cl₂N₆S₂ 
• 96540-00-0 1-[4,6-Bis-(4-chloro-phenylamino)-[1,3,5]triazin-2-yloxy]-propan-2-one 
• 77427-12-4 8-(4-Chloro-phenyl)-2-(4-chloro-phenylamino)-6-methylene-7,8-dihydro-6H-imidazo[1,2-a][1,3,5]triazin-4-one 
• 76479-24-8 N,N'-Bis-(4-chloro-phenyl)-N''-[1-phenyl-meth-(E)-ylidene]-[1,3,5]triazine-2,4,6-triamine 

Relevant articles and documents

Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives

A series of 4-aminoquinoline 1,3,5-triazine derivatives were synthesized and evaluated for anticancer activity against cancer cell lines HeLa, MCF-7, HL-60, HepG2 where these derivatives exert significant anticancer activity. The molecules found nontoxic against MCF-12A. The molecules also showed potent inhibition of EGFR-TK as compared to eroltinib in enzyme-based assay. The newly synthesized derivatives were screened for their in vitro antibacterial and antifungal activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, Aspergillus niger, Aspergillus fumigatus using cefixime and fluconazole as standard. Antibacterial screening results suggest that compound 7c showed potent activity against S. aureus, P. aeruginosa, and P. vulgaris. In antifungal screening, compound 7b showed significant activity against A. niger, A. fumigatus and moderate activity against C. albicans.

Structure-guided discovery of 1,3,5-triazine-pyrazole conjugates as antibacterial and antibiofilm agent against pathogens causing human diseases with favorable metabolic fate

Impressed by the exceptional antibacterial activity exhibited by our earlier designed molecules originating from 1,3,5-triazine, the present study was undertaken to synthesize a novel series of 1,3,5-triazine-pyrazole conjugates to bring diversity around the core skeleton. The target analogues showed potent antibacterial activity against tested Gram-positive and Gram-negative microorganisms. The toxicity and metabolic site prediction studies were also held out to set an effective lead candidate for the future antibacterial drug discovery initiatives.

4-Aminoquinoline-1,3,5-triazine: Design, synthesis, in vitro antimalarial activity and docking studies

A series of hybrid 4-aminoquinoline 1,3,5-triazine derivatives was synthesized and their chemical structure were confirmed by 1H-NMR, 13C-NMR, FT-IR and mass spectrometric analyses. In vitro antimalarial activity of these compounds was evaluated against chloroquine-sensitive (3D-7) and chloroquine resistant (RKL-2) strains of P. falciparum. Results showed that all compounds had considerable antimalarial activity against both the strains and further docking studies were performed on both wild type (1J3I.pdb) and quadruple mutant (N51I, C59R, S108 N, I164L, 3QG2.pdb) pf-DHFR-TS to quantify the structural parameter necessary for the activity.