257277-49-9

Upstream product

• 108-24-7 acetic anhydride 
• 257277-48-8 tert-Butyl-((3aR,5S,6R,6aR)-6-[1,3]dithian-2-yl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethoxy)-diphenyl-silane 

Downstream Products

• 257277-55-7 C₆₂H₇₁N₅O₁₄Si 
• 257277-54-6 C₆₀H₆₉N₅O₁₃Si 
• 257277-53-5 C₅₅H₆₉N₅O₁₁Si₂ 
• 257277-56-8 C₄₆H₅₃N₅O₁₄ 
• 324021-06-9 C₄₄H₅₁N₅O₁₃ 
• 257277-51-3 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-[1,3]dithian-2-yl-3-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 257277-52-4 3'-deoxy-3'-C-formyl-5-methyluridine 

Relevant academic research and scientific papers

A new approach for the synthesis of 3'-deoxy-3'-C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2'-OH and 2'-OMe groups

A stereoselective synthesis of 3'-deoxy-3'-C-formyl-5-methyluridine 2 is described via the dithiane 4 as the key intermediate. Compound 2 was coupled with 3 into a novel ribo-MMI dimer 1. The dimer was then incorporated into antisense oligonucleotides which were found to have high binding affinity to the target RNA. (C) 2000 Elsevier Science Ltd.