257277-52-4

Upstream product

• 3444-09-5 1,3-bis(trimethylsilyl)thymine 
• 257277-50-2 acetic acid 5-(tert-butyl-diphenyl-silanyloxymethyl)-4-[1,3]dithian-2-yl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 257277-49-9 Acetic acid (2S,3R,4R,5S)-2-acetoxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-[1,3]dithian-2-yl-tetrahydro-furan-3-yl ester 
• 257277-48-8 tert-Butyl-((3aR,5S,6R,6aR)-6-[1,3]dithian-2-yl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethoxy)-diphenyl-silane 
• 257277-45-5 ((3aR,5S,6aR)-6-[1,3]Dithian-2-ylidene-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethoxy)-triisopropyl-silane 
• 257277-46-6 ((3aR,5S,6aR)-6-[1,3]Dithian-2-ylidene-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol 
• 257277-51-3 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-[1,3]dithian-2-yl-3-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 324021-06-9 C₄₄H₅₁N₅O₁₃ 
• 257277-56-8 C₄₆H₅₃N₅O₁₄ 
• 257277-54-6 C₆₀H₆₉N₅O₁₃Si 
• 257277-55-7 C₆₂H₇₁N₅O₁₄Si 
• 257277-53-5 C₅₅H₆₉N₅O₁₁Si₂ 

Relevant academic research and scientific papers

Chimeric RNA with modified backbones: Alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2′-OH and 2′-OMe groups

Synthesis of a novel ribo-MMI dimer with 2′-OH and 2′-OMe in 5′- and 3′-nucleosides, respectively is presented. The synthesis was accomplished by reductive coupling of 3′-deoxy-3′-C-formyluridine and 2′-O-methyl-5′-O-methylaminouridine via a thioacetal as

A new approach for the synthesis of 3'-deoxy-3'-C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2'-OH and 2'-OMe groups

A stereoselective synthesis of 3'-deoxy-3'-C-formyl-5-methyluridine 2 is described via the dithiane 4 as the key intermediate. Compound 2 was coupled with 3 into a novel ribo-MMI dimer 1. The dimer was then incorporated into antisense oligonucleotides which were found to have high binding affinity to the target RNA. (C) 2000 Elsevier Science Ltd.