257292-10-7Relevant articles and documents
Hydrophobic benzoic acids as inhibitors of influenza neuraminidase
Atigadda, Venkatram R.,Brouillette, Wayne J.,Duarte, Franco,Babu, Yarlagadda S.,Bantia, Shanta,Chand, Pooran,Chu, Naiming,Montgomery, John A.,Walsh, David A.,Sudbeck, Elise,Finley, James,Air, Gillian M.,Luo, Ming,Laver, Graeme W.
, p. 2487 - 2497 (2007/10/03)
Neuraminidase (NA) plays a critical role in the life cycle of influenza virus and is a target for new therapeutic agents. A new benzoic acid inhibitor (11) containing a lipophilic side chain at C-3 and a guanidine at C-5 was synthesized. The X-ray structu