25742-65-8

Basic information

• Product Name: Isoxazole, 3-(2-chlorophenyl)-
• CAS NO: 25742-65-8
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.606
• Mol File: 25742-65-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Isoxazole, 3-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3-(2-chlorophenyl)-(25742-65-8)
• EPA Substance Registry System: Isoxazole, 3-(2-chlorophenyl)-(25742-65-8)

Safety Data

• Hazardous Substances Data: 25742-65-8(Hazardous Substances Data)

Upstream product

• 112853-60-8 3-(2-chlorophenyl)-5-hydroxy-2-isoxaline 
• 1794-45-2 2-chlorocinnamaldehyde 
• 49660-38-0 2-chlorobenzonitrile oxide 
• 108-05-4 vinyl acetate 
• 3717-28-0 2-chloro benzaldehyde oxime 

Downstream Products

• 873-32-5 2-Chlorobenzonitrile 
• 1093649-70-7 3-(N,N-diisopropylamino)benzonitrile 

Relevant articles and documents

Polymer-supported vinyl sulfone as an efficient reagent for the synthesis of 3-monosubstituted isoxazoles

Polystyrene-supported vinyl sulfone reagent has been developed and used for solid-phase organic synthesis of 3-monosubstituted isoxazoles by 1,3-dipolar cycloaddition reaction with nitrile oxides and subsequent cleavage from the polymer support through an

Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA

3-Arylisoxazoles react with LDA in THF at 0 °C affording syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones (bis-azetidinones), via stereoselective dimerization of an azetinone anion intermediate. A?fragmentation reaction affording arylnitriles may compete with electronic and steric effects of the substituent present in the aryl group being pivotal in determining the outcome of this reaction. An interesting behaviour with LDA of arylnitriles arising from the fragmentation reaction of some 3-arylisoxazoles was also observed. N,N-Diisopropylaminobenzonitriles were in fact formed (plausibly via a benzyne mechanism) from 3-(4-chlorophenyl)isoxazole and 3-(2-chlorophenyl)isoxazole, whereas 3-(2-methylphenyl)isoquinolin-1-amine was isolated starting from 3-(2-methylphenyl)isoxazole and LDA.