2576-67-2

Usage

Uses

Used in Pharmaceutical Research:
H-GLY-LEU-GLY-OH is used as a research compound for exploring its potential biological activities and pharmacological effects. Its unique sequence may contribute to specific functions in cell signaling and immune response, providing insights into the development of new therapeutic agents.
Used in Drug Development:
H-GLY-LEU-GLY-OH is utilized as a lead compound in drug discovery, owing to its potential biological properties. Its unique amino acid sequence may offer advantages in the design of novel drugs targeting various diseases and conditions.
Used in Cosmetics Industry:
H-GLY-LEU-GLY-OH is used as an active ingredient in cosmetic products for its potential skin benefits. The peptide may contribute to skin hydration, elasticity, and overall health, making it a valuable component in skincare formulations.
Used in Nutraceuticals:
H-GLY-LEU-GLY-OH is employed as a nutraceutical ingredient, leveraging its potential health benefits. The peptide may support immune function and overall well-being when incorporated into dietary supplements and functional foods.

InChI:InChI=1/C10H19N3O4/c1-6(2)3-7(13-8(14)4-11)10(17)12-5-9(15)16/h6-7H,3-5,11H2,1-2H3,(H,12,17)(H,13,14)(H,15,16)

Upstream product

• 16816-39-0 N-[N-(N-benzyloxycarbonyl-glycyl)-L-leucyl]-glycine methyl ester 
• 7325-21-5 glycyl-L-leucylglycylglycine 
• 102895-76-1 N-benzoyloxycarbonylglycyl-L-leucylglycine benzylester 
• 1421-69-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoic acid 
• 27560-15-2 methyl 2-(2-amino-4-methylpentanamido)acetate 

Downstream Products

• 16295-42-4 N-{N-[N-(N-benzyloxycarbonyl-glycyl)-glycyl]-L-leucyl}-glycine 
• 98282-21-4 benzoyl-Gly-Leu-Gly 

Relevant academic research and scientific papers

Thermodynamic Properties of Peptide Solutions Part 6. The Amino Acid Side-chain Contributions to the Partial Molar Volumes and Heat Capacities of some Tripeptides in Aqueous Solution

Limiting partial molar volumes, V02, and partial molar heat capacities, C0p,2, have been determined for the tripeptides glycyl-L-valylglycine, glycyl-DL-serylglycine and the D and L isomers of glycylleucylglycine in aqueous solution at 298.15 K.These V02 and C0p,2 results, in conjunction with those for glycylglycylglycine, were used to estimate the contribution of the side chains to the thermodynamic properties.The results obtained are compared with those estimated using V02 and C0p,2 data for amino acids and dipeptides.The comparison suggests that the tripeptides of sequence glycyl-X-glycine are reasonable models for estimating the contribution to the thermodynamic properties of proteins made by solvent-accessible side chains.

Model studies of competing hydrolysis and epimerization of some tetrapeptides of interest in amino acid racemization studies in geochronology

The processes of epimerization of individual peptide units in proteins and the concurrent cleavage of peptide bonds are modelled by heating some tetrapeptide and tetrapeptide derivatives to 148.5 deg C in pH 6.8 phosphate buffer.An excess of D-proline was observed during the heating of L-propyl-L-leucylglycylglycine.The D/L ratio of proline attains a maximum value of 2.1 after 90 minutes.The excess D-proline is attributed to the formation of a 2.3:1 mixture of diketopiperazines cyclo-(D-propyl-L-leucyl) and cyclo-(L-prolyl-L-leucyl).These two species account for most of the leucine and proline in the final mixture after the tetrapeptide is no longer detectable.Only small amounts of prolylleucine can be detcected after 50 hours.It is suggested that the above tetrapeptide undergoes internal aminolysis.Leucine in the tetrapeptide glycyl-L-leucylglycylglycine racemizes three times faster than in L-propyl-L-leucylglycylglycine.This demonstrates that an amino acid residue in a peptide chain does have an effect upon the rate of epimerization of a neighbouring peptide residue.A discussion of the geochemical implications of the results is included.