257638-95-2Relevant academic research and scientific papers
THIAZOLIDINE DERIVATIVES
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, (2008/06/13)
An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented by the following general formula [I] and salts thereof, wherein R 1is alkyl, hydroxy, alkoxy, alkoxyalkyl, phenyl, phenylalkyl, phenylalkoxy, phenoxy, phenoxyalkyl, amino, alkylamino or a nonaromatic heterocycle; R 2is H or alkyl; R 3is H, alkyl or phenyl; R 4is H or alkyl; R 5is alkyl, halogenoalkyl, hydroxy, alkoxy, phenyl, phenylalkoxy, phenoxy, carboxyl, alkoxycarbonyl, phenylalkoxycarbonyl or an aromatic heterocycle; A 1is alkylene; and A 2is alkylene.
Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT1 receptor
Johannesson, Petra,Lindeberg, Gunnar,Johansson, Anja,Nikiforovich, Gregory V.,Gogoll, Adolf,Synnergren, Barbro,Le Grèves, Madeleine,Nyberg, Fred,Karlén, Anders,Hallberg, Anders
, p. 1767 - 1777 (2007/10/03)
Vinyl sulfide cyclized analogues of the octapeptide angiotensin II that are structurally related to the cyclic disulfide agonist c[Hcy3,5 Ang II have been prepared. The synthesis relies on the reaction of the mercapto group of a cysteine residu
