25772-91-2

Basic information

• Product Name: 1-chloro-3-(2-methylphenoxy)propan-2-ol
• Synonyms: 1-Chloro-3-(2-methylphenoxy)propan-2-ol; 2-propanol, 1-chloro-3-(2-methylphenoxy)-
• CAS NO: 25772-91-2
• Molecular Formula: C₁₀H₁₃ClO₂
• Molecular Weight: 200.662
• EINECS: 607-807-2
• Mol File: 25772-91-2.mol

Chemical Properties

• Boiling Point: 321.392°C at 760 mmHg
• Flash Point: 148.173°C
• Density: 1.167g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: 1-chloro-3-(2-methylphenoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-(2-methylphenoxy)propan-2-ol(25772-91-2)
• EPA Substance Registry System: 1-chloro-3-(2-methylphenoxy)propan-2-ol(25772-91-2)

Safety Data

• Hazardous Substances Data: 25772-91-2(Hazardous Substances Data)

Upstream product

• 95-48-7 ortho-cresol 
• 106-89-8 epichlorohydrin 
• 56-23-5 tetrachloromethane 
• 7732-18-5 water 

Downstream Products

• 20807-66-3 3-hydroxy-4-(2-methylphenoxy)butanenitrile 
• 1649-95-2 2-Hydroxy-3-o-tolyloxy-propylfluorid 
• 76596-62-8 1-chloro-3-(o-tolyloxy)propan-2-one 
• 1542-53-6 2-Hydroxy-3-o-tolyloxypropylfluorid-carbamat 
• 20807-68-5 4-(o-Tolyloxy)-3-hydroxy-buttersaeureamid 
• 20807-69-6 4-(o-Tolyloxy)-3-hydroxy-buttersaeure 
• 77216-23-0 1-[[2-(5-methoxy-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 77216-22-9 1-[[2-(5-bromo-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 72742-77-9 1-[[1,1-dimethyl-2-(2-methyl-3-indolyl)ethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 77216-21-8 1-[[2-(1-methyl-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 77216-17-2 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 63991-86-6 Acetic acid 1-acetoxymethyl-2-o-tolyloxy-ethyl ester 
• 59-47-2 mephenesin 
• 85833-33-6 o-Tolyl-carbamic acid 1-butylsulfanylmethyl-2-o-tolyloxy-ethyl ester 

Relevant articles and documents

Asymmetric reduction of α-thiocyanatoketones by Saccharomyces cerevisiae and Mortierella isabellina-a new route to optically active thiiranes

A simple method for the preparation of optically active 1-aryloxy- and 1-arylsulphanyl-3-thiocyanatopropan-2-oles from racemic 1-chloro-3-aryloxy- and 1-chloro-3-arylsulphanyl-2-propanols via 1-aryloxy- and 1-arylsulphanyl-3-thiocyanatopropan-2-ones has been developed. The enantiomerically enriched β-hydroxythiocyanates were obtained by a microbiological reduction of the thiocyanatoketones with Saccharomyces cerevisiae or Mortierella isabellina and subsequently converted into optically active thiiranes on treatment with a lithium hydroxide solution.

Improvement and simplification of synthesis of 3-aryloxy-1,2-epoxypropanes using solvent-free conditions and microwave irradiations. Relation with medium effects and reaction mechanism

Some 3-aryloxy-1,2-epoxypropanes, interesting as potential synthons in β-adrenergic receptor antagonists preparation, were obtained in excellent yields (65-96% within 2-17 min) by microwave activation (monomode system) using solid-liquid solvent-free phase transfer catalysis (PTC). The best results for the O-alkylation of some phenols with epichlorohydrin were obtained using TBAB and NaOH/K2CO3 (1:4 mol/mol) as phase transfer catalyst and more acceptable basic system, respectively. These new procedure is compared with classical methods. Significant specific microwave effect (non-purely thermal) was evidenced in all cases. They were discussed in terms of reaction medium and mechanism, taking into account the variations in polarity of the systems.

Synthesis of [14C]-Labelled glycidyl and glycerol ethers of aliphatic and aromatic alcohols.

The synthesis of [14C]-labelled glycidyl ethers and the corresponding glycerol ethers is described for the monofunctional compounds 1-dodecanol and ortho-cresol and the bifunctional compounds 4,4'-dihydroxy-3,3',5,5'-tetramethyl biphenyl and 1,6-hexanediol. The synthesis is based on reaction between the alcohol and [U-14C]-epichlorohydrin. The aromatic compounds have been converted to the corresponding glycidyl ethers by using sodium hydroxide and the aliphatic compounds by using tin(IV) chloride as a catalyst. Thus radio-labelled glycidyl ethers were obtained in yields between 50-80, with a chemical purity of > 92 and a radiochemical purity of > 95 by HPLC. The specific activities of the glycidyl ethers were approximately 0.2 mCi/mmol for the monofunctional compounds and approximately 0.4 mCi/mmol for the bifunctional compounds.

Antihypertensive indole derivatives of phenoxypropanolamines with β-adrenergic receptor antagonist and vasodilating activity

A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl[i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), β-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with β-adrenergic receptor antagonist and vasodilating action. The structure-activity relationships in these tests are discussed.