25772-94-5Relevant academic research and scientific papers
DIAZEPINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS B INFECTIONS
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Page/Page column 135-136, (2018/02/28)
Provided herein are compounds of formula (I) and (V) useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
Samarium(III) triflate catalyzed conjugate addition of amines to electron-deficient alkenes
Yadav,Ramesh Reddy,Gopal Rao,Narsaiah,Subba Reddy
, p. 3447 - 3450 (2008/09/19)
Amines undergo smooth nucleophilic addition to α,β-unsaturated compounds in the presence of a catalytic amount of samarium(III) triflate at ambient temperature to produce the corresponding β-amino compounds in excellent yields. This method is simple, convenient, and works efficiently under mild conditions. Georg Thieme Verlag Stuttgart.
Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core
Dyck, Brian,Grigoriadis, Dimitri E.,Gross, Raymond S.,Guo, Zhiqiang,Haddach, Mustapha,Marinkovic, Dragan,McCarthy, James R.,Moorjani, Manisha,Regan, Collin F.,Saunders, John,Schwaebe, Michael K.,Szabo, Tomas,Williams, John P.,Zhang, Xiaohu,Bozigian, Haig,Chen, Ta Rung
, p. 4100 - 4110 (2007/10/03)
Two new classes of tricyclic-based corticotropin-releasing factor (CRF 1) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine ligands. Pyrrole- and pyrazole-based molecules 19g and
Methods and compounds for treating depression and other disorders
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, (2008/06/13)
The present invention features compounds active at both the serotonin reuptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin reuptake site and the NMDA receptor (“multi-active compounds”) can be used to treat different types of disorders such as depression, obsessive-compulsive disorders (OCD), sleep, disorders, sexual dysfunction, and eating disorders. Preferably, the multi-active compounds are used to treat depression.
Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
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, (2008/06/13)
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cogniti
Cerium(IV) oxidations of β-aminoketones, VIII: Synthesis of 1,2,3,4-tetrahydroisoquinolines with differently substituted piperidine parts
Holzgrabe,Inkman
, p. 209 - 215 (2007/10/02)
1- and 3-Alkyl- and/or aryl substituted tetrahydroisoquinolines are obtained by oxidative cyclisation of N-benzyl-β-aminoketones with cerium(IV) sulphate. In nearly all cases formation of mixtures of diastereomeres is observed. If the ketone function is r
