257869-92-4

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 66-22-8 uracil 

Downstream Products

• 4113-97-7 uracilacetic acid 
• 1443322-54-0 C₃₄H₃₄N₆O₈ 
• 1443322-79-9 tert-butyl 2-(4-((2-(2-nitrophenyl)propyl)amino)-2-oxopyrimidin-1(2H)-yl)acetate 
• 1443322-84-6 2-(4-((2-(2-nitrophenyl)propyl)amino)-2-oxopyrimidin-1(2H)-yl)acetic acid 
• 1443322-89-1 C₃₈H₄₂N₆O₈ 

Relevant academic research and scientific papers

Nucleobase-caged peptide nucleic acids: PNA/PNA duplex destabilization and light-triggered PNA/PNA recognition

The 2-(o-nitrophenyl)-propyl (NPP) group is used as caging group to mask the nucleobases adenine and cytosine in N-(2-aminoethyl)glycine peptide nucleic acids (aeg-PNA). The adeninyl and cytosinyl nucleo amino acid building blocks Fmoc-aNPP-aeg

Cyclic PNA hexamer-based compound: Modelling, synthesis and inhibition of the HIV-1 RNA dimerization process

A cyclic molecule constituted by (i) a hexameric PNA moiety complementary to six among the nine residues of the dimerization initiation site loop of HIV-1 and (ii) a spacer tethering the N- to the C-extremities of the PNA, has been elaborated to inhibit the dimerization process of HIV-1 genome. This compound has been synthesized following a liquid-phase procedure (fully protected backbone approach). Preliminary agarose gel electrophoresis analyses have shown that the cyclic PNA conjugate is able to inhibit the HIV-1 dimerization.