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5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-ylamine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

257871-22-0

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257871-22-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 257871-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,7,8,7 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 257871-22:
(8*2)+(7*5)+(6*7)+(5*8)+(4*7)+(3*1)+(2*2)+(1*2)=170
170 % 10 = 0
So 257871-22-0 is a valid CAS Registry Number.

257871-22-0Downstream Products

257871-22-0Relevant articles and documents

5-Aryl-pyrazolo[3,4-b]pyridazines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Witherington, Jason,Bordas, Vincent,Haigh, David,Hickey, Deirdre M. B.,Ife, Robert J.,Rawlings, Anthony D.,Slingsby, Brian P.,Smith, David G.,Ward, Robert W.

, p. 1581 - 1584 (2003)

Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4-b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding mode suggested participation of a putative structural water molecule, which was subsequently confirmed by X-ray crystallography.

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases

Bra?a, Miguel F.,Cacho, Mónica,García, M. Luisa,Mayoral, Elena P.,López, Berta,De Pascual-Teresa, Beatriz,Ramos, Ana,Acero, Nuria,Llinares, Francisco,Mu?oz-Mingarro, Dolores,Lozach, Olivier,Meijer, Laurent

, p. 6843 - 6854 (2007/10/03)

Pyrazolopyridazine 1a was identified in a high-throughput screening carried out by BASF Bioresearch Corp. (Worcester, MA) as a potent inhibitor of CDK1/cyclin B and shown to have selectivity for the CDK family. Analogues of the lead compound have been syn

Pyrazolopyridines and pyrazolopyridazines as antidabetics

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Page/Page column 21, (2010/02/05)

The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; R1 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclyl and the alkyl moieties may each independently be unsubstituted or substituted; and R2 is unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention includes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.

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