87769-56-0Relevant articles and documents
5-Aryl-pyrazolo[3,4-b]pyridazines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason,Bordas, Vincent,Haigh, David,Hickey, Deirdre M. B.,Ife, Robert J.,Rawlings, Anthony D.,Slingsby, Brian P.,Smith, David G.,Ward, Robert W.
, p. 1581 - 1584 (2007/10/03)
Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4-b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding mode suggested participation of a putative structural water molecule, which was subsequently confirmed by X-ray crystallography.
3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities
Wermuth,Schlewer,Bourguignon,Maghioros,Bouchet,Moire,Kan,Worms,Biziere
, p. 528 - 537 (2007/10/02)
Minaprine [3[(β-morpholinoethyl)amino]4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effe
Pyridazine derivatives having a psychotropic action and compositions
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, (2008/06/13)
This invention relates to pyridazine derivatives substituted in the 4-position by a cyano group having psychotropic activity. It also relates to a process for the preparation of these products and their application as medicaments. STR1
