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AWD-12-281 is a chemical compound with notable anti-inflammatory and anti-cancer properties. It effectively inhibits the activation of key signaling pathways such as NF-κB and Akt, which are involved in inflammation and cancer progression. Additionally, AWD-12-281 can induce cell cycle arrest and apoptosis in cancer cells, positioning it as a potential candidate for the development of new anti-cancer drugs. Its minimal toxicity in normal cells suggests a favorable safety profile for clinical use, making it a promising novel therapeutic agent for the treatment of inflammatory diseases and cancer.

257892-33-4

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257892-33-4 Usage

Uses

Used in Pharmaceutical Industry:
AWD-12-281 is used as a potential anti-cancer drug for its ability to inhibit the activation of NF-κB and Akt pathways, which play a crucial role in cancer progression. Its capacity to induce cell cycle arrest and apoptosis in cancer cells makes it a valuable candidate for the development of new cancer treatments.
Used in Anti-Inflammatory Applications:
In the field of anti-inflammatory therapy, AWD-12-281 is utilized for its anti-inflammatory properties, as it can inhibit the activation of inflammatory signaling pathways, thereby potentially reducing inflammation in various diseases.
Used in Drug Safety Research:
Due to its minimal toxicity in normal cells, AWD-12-281 is used in research to explore its safety profile, which is essential for the development of drugs with fewer side effects and better tolerability in clinical settings.

Check Digit Verification of cas no

The CAS Registry Mumber 257892-33-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,7,8,9 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 257892-33:
(8*2)+(7*5)+(6*7)+(5*8)+(4*9)+(3*2)+(2*3)+(1*3)=184
184 % 10 = 4
So 257892-33-4 is a valid CAS Registry Number.

257892-33-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide

1.2 Other means of identification

Product number -
Other names AWD 12-281

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:257892-33-4 SDS

257892-33-4Downstream Products

257892-33-4Relevant academic research and scientific papers

METHOD FOR PRODUCING HIGHLY PURE HYDROXY INDOLYL GLYOXYLIC ACID AMIDES

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Page/Page column 13; 15, (2010/11/30)

The invention relates to a method for producing hydroxy indolyl glyoxylic acid amides in high yields and in a particularly pure form.

Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation

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, (2008/06/13)

The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.

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